1003024-00-7

Basic information

• Product Name: 20-Deoxo-20-(1-piperidinyl)tylosin
• Synonyms: 20-Deoxo-20-(1-piperidinyl)tylosin;FCHGJLYPEOOKAB-UVNBROOPSA-N
• CAS NO: 1003024-00-7
• Molecular Formula: C51H88N2O16
• Molecular Weight: 985.24822
• Product Categories: Chiral Reagents, Carbohydrates & Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1003024-00-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DCM, Toluene
• CAS DataBase Reference: 20-Deoxo-20-(1-piperidinyl)tylosin(CAS DataBase Reference)
• NIST Chemistry Reference: 20-Deoxo-20-(1-piperidinyl)tylosin(1003024-00-7)
• EPA Substance Registry System: 20-Deoxo-20-(1-piperidinyl)tylosin(1003024-00-7)

Safety Data

• Hazardous Substances Data: 1003024-00-7(Hazardous Substances Data)

Usage

Description

20-Deoxo-20-(1-piperidinyl)tylosin is a chemical compound that serves as an intermediate in the synthesis of Tylosin, a macrolide antibiotic derived from a strain of Streptomyces fradiae, which is found in soil samples from Thailand. 20-Deoxo-20-(1-piperidinyl)tylosin plays a crucial role in the production of Tylosin, contributing to its pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
20-Deoxo-20-(1-piperidinyl)tylosin is used as an intermediate in the synthesis of Tylosin for its antibiotic properties. Tylosin, a macrolide antibiotic, is effective against a range of bacterial infections, making it a valuable component in the development of antibiotics for medical use.
Additionally, as an intermediate in the synthesis of Tylosin (T947650), 20-Deoxo-20-(1-piperidinyl)tylosin contributes to the production of a compound that has potential applications in veterinary medicine, where it can be used to treat bacterial infections in animals.

Upstream product

• 110-89-4 piperidine 
• 1401-69-0 tylosin 

Downstream Products

• 1003024-01-8 (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-7-(2-(piperidin-1-yl)ethyl)oxacyclohexadeca-11,13-diene-2,10-dione 
• 328898-40-4 20,23-dipiperidin-5-O-mycaminosyl tylonolide 

Relevant articles and documents

Synthesis and purification method of tildipirosin

The invention discloses a synthesis and purification method of tildipirosin. The method comprises the following steps of dissolving tylosin phosphate in an organic solvent, adding formic acid and piperidine, and performing a heating reaction; performing cooling, adding water and hydrobromic acid, and performing standing for layering; hydrolyzing an aqueous solution A, performing cooling, adding the organic solvent, and performing standing for layering; adding alkali into a water phase to adjust the pH value to 6.5-7.0, adding the organic solvent and alkali to adjust the pH value to be greater than 13, performing standing for layering to obtain a filtrate, and controlling the water content to be less than 0.1% through atmospheric distillation; adding triphenylphosphine and pyridine, performing heating, dropwise adding an iodine solution, continuously reacting, performing cooling, adding alkali for quenching, and performing standing for layering; adding an alkali catalyst and piperidine into the filtrate C, performing a heating reaction, performing cooling, adding acid to adjust the pH value to 6.20-6.80, and performing standing for layering; adding the organic solvent into the water phase, and performing standing for layering; and continuously adding the organic solvent and the alkali into the water phase to adjust the pH value to be greater than 13, and performing standing for layering to obtain a filtrate D. The method is simple to operate, mild in reaction condition, low in cost and high in product yield, and the purity and content of the obtained tildipirosin are both greater than 99%; and the method is beneficial to industrial production.