100342-30-1

Basic information

• Product Name: N-tert-Butyl-2-thiophenesulfonamide
• Synonyms: N-tert-Butyl-2-thiophenesulfonamide;N-(1,1-Dimethylethyl)-2-thiophenesulfonamide;N-(tert-Butyl)thiophene-2-sulphonamide;2-Thiophenesulfonamide, N-(1,1-dimethylethyl)-;N-tert-Butyl-2-thiophenesulfonamide
• CAS NO: 100342-30-1
• Molecular Formula: C₈H₁₃NO₂S₂
• Molecular Weight: 219.32
• Product Categories: API intermediates;Thiophene intermediates
• Mol File: 100342-30-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 82.0 to 86.0 °C
• Boiling Point: 321 °C
• Flash Point: 148 °C
• Appearance: /
• Density: 1.224
• Vapor Pressure: 0.000311mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: 2-8°C(protect from light)
• Solubility: soluble in Methanol
• PKA: 11.86±0.50(Predicted)
• CAS DataBase Reference: N-tert-Butyl-2-thiophenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyl-2-thiophenesulfonamide(100342-30-1)
• EPA Substance Registry System: N-tert-Butyl-2-thiophenesulfonamide(100342-30-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 100342-30-1(Hazardous Substances Data)

Usage

General Description

N-tert-Butyl-2-thiophenesulfonamide is a chemical compound that is commonly used as a pharmaceutical intermediate and in the synthesis of various pharmaceutical drugs. It is a sulfonamide derivative with a tert-butyl group attached to the nitrogen atom and a thiophene ring. N-tert-Butyl-2-thiophenesulfonamide has been studied for its potential therapeutic applications, including as an anticonvulsant and antihypertensive agent. Additionally, it has been used in the development of new drugs for the treatment of various medical conditions. N-tert-Butyl-2-thiophenesulfonamide has also been investigated for its potential as a corrosion inhibitor in industrial applications. Overall, this chemical compound has shown promise for various applications in pharmaceutical and industrial settings.

InChI:InChI=1/C8H13NO2S2/c1-8(2,3)9-13(10,11)7-5-4-6-12-7/h4-6,9H,1-3H3

Upstream product

• 16629-19-9 thiophene-2-sulfonyl chloride 
• 75-64-9 tert-butylamine 
• 6339-87-3 2-thiophensulfonamide 
• 507-19-7 t-butyl bromide 
• 691-64-5 di-tert-butyl oxalate 

Downstream Products

• 146013-28-7 N-(tert-butyl)-5-isobutylthiophene-2-sulphonamide 
• 1168076-29-6 5-(4-methoxyphenyl)thiophene-2-sulphonic acid tert-butylamide 
• 477775-35-2 3-(4-imidazol-1-ylmethylphenyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide 
• 6339-87-3 2-thiophensulfonamide 
• 147214-19-5 5-butyl-3-[(4-hydroxymethyl)phenyl]-2-(N-t-butylaminosulfonyl)thiophene 

Relevant articles and documents

Zn- And Cu-catalyzed coupling of tertiary alkyl bromides and oxalates to forge challenging C?O, C?S, and C?N bonds

We describe here the facile construction of sterically hindered tertiary alkyl ethers and thioethers via the Zn(OTf)2catalyzed coupling of alcohols/phenols with unactivated tertiary alkyl bromides and the Cu(OTf)2-catalyzed thiolation of unactivated tertiary alkyl oxalates with thiols. The present protocol represents one of the most effective unactivated tertiary C(sp3)? heteroatom bond-forming conditions via readily accessible Lewis acid catalysis that is surprisingly less developed.

NEW TRICYCLIC ANGIOTENSIN II AGONISTS

There is provided compounds of formula (I) wherein the dotted line, X1, X2, X3, A, Y1, Y2, Y3, Y4, Z1, Z2, R2 and R3 have meanings giv

NEW TRICYCLIC ANGIOTENSIN II AGONISTS

There is provided compounds of Formula (I), wherein A, X1, X2, X3, X4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceuticalfy-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.