100361-18-0

Basic information

• Product Name: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• Synonyms: 7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridin-3-Carboxylic Acid;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyl ridine carbox.acid;7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Qxoquinoline-3-CarboxylicAcid98%;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacid;7-Chloro-1-cyclopropyl-6-fluor;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-Ox;7-Chloro-1-cyclopropyl-1,4-dihydro-3-oxo-1,8-naphthyridine-3-carboxylic aci;1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLRIDINE CARBOXYLIC ACID 99%
• CAS NO: 100361-18-0
• Molecular Formula: C₁₂H₈ClFN₂O₃
• Molecular Weight: 282.65
• EINECS: 1312995-182-4
• Product Categories: Heterocycles;Intermediate;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorine series
• Mol File: 100361-18-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 209-212 °C
• Boiling Point: 485.919 °C at 760 mmHg
• Flash Point: 247.675 °C
• Appearance: White powder
• Density: 1.727 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.96±0.70(Predicted)
• CAS DataBase Reference: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(100361-18-0)
• EPA Substance Registry System: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(100361-18-0)

Safety Data

• Hazardous Substances Data: 100361-18-0(Hazardous Substances Data)

Usage

Description

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid is a chemical compound with a complex structure, characterized by its off-white or light yellow powder appearance. It is a derivative of naphthyridine, a type of fused heterocyclic compound, and possesses a unique combination of functional groups that contribute to its chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid is used as an intermediate for the synthesis of Gemifloxacin, a fluoroquinolone antibiotic. It serves as a key component in the development of this potent antibacterial agent, which is effective against a wide range of bacterial infections, including respiratory and skin infections.
As a Gemifloxacin intermediate, 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid plays a crucial role in the pharmaceutical industry, contributing to the production of an essential antibiotic that helps combat bacterial infections and improve public health.

InChI:InChI=1/C12H8ClFN2O3/c13-10-8(14)3-6-9(17)7(12(18)19)4-16(5-1-2-5)11(6)15-10/h3-5H,1-2H2,(H,18,19)

Upstream product

• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 
• 122-51-0 orthoformic acid triethyl ester 
• 765-30-0 Cyclopropylamine 
• 96568-07-9 ethyl-7-chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 99735-36-1 4-[6-(acetylcyclopropylamino)-3-fluoro-2-pyridinyl]-1-piperazine-carboxylic acid,ethyl ester 
• 99735-42-9 1-cyclopropyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 96568-06-8 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate 

Downstream Products

• 122536-87-2 7-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 
• 99735-41-8 ciprofloxacin 
• 113533-65-6 1-cyclopropyl-6-fluoro-1,4-dihydro-7-<3-<(methylamino)methyl>-1-pyrrolidinyl>-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 175463-14-6 gemifloxacin 

Relevant articles and documents

Quinolone Antibacterials Containing the New 7- Side Chain: The Effects of the 1-Aminoethyl Moiety and Its Stereochemical Configurations on Potency and in Vivo Efficacy

A series of stereochemically pure 7--1,4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-3-(1-aminoe

Structure aided design of chimeric antibiotics

The rise of antibiotic resistance is of great clinical concern. One approach to reducing the development of resistance is to co-administer two or more antibiotics with different modes of action. However, it can be difficult to control the distribution and

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1

In an attempt to search for clinically useful antitumor agents, we have discovered that a series of 1,7-disubstituted-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids possessed moderate cytotoxic activity. We investigated the structure-acti