1003867-54-6Relevant articles and documents
Tandem Deoxygenation/Halogenation of N-Oxides Under Acylation Conditions: Scope and In Situ IR Spectroscopic Study
Malykhin, Roman S.,Golovanov, Ivan S.,Ioffe, Sema L.,Sukhorukov, Alexey Yu.
, p. 4139 - 4148 (2019/04/03)
Acylation of cyclic nitronates with acyl bromides produces 3-bromomethyl-substituted 5,6-dihydro-2H-1,2-oxazines via an unusual multi-stage process involving deoxygenation of N-oxide and the formation of Br2. Low-temperature in situ ATR FT-IR monitoring and DFT calculations revealed α-halo-substituted N,N-bis(oxy)amines as key intermediates of the process. The developed method was successfully exploited in the stereoselective synthesis of pharmaceutically relevant molecules.
A convenient procedure for the synthesis of N-acetyl-5,6-dihydro-2H-1,2- oxazines
Ivashkin, Pavel E.,Sukhorukov, Alexey Yu.,Eliseev, Oleg L.,Lesiv, Alexey V.,Khomutova, Yulja A.,Ioffe, Sema L.
, p. 3461 - 3468 (2008/09/19)
Acetylation of 5,6-dihydro-4H-1,2-oxazines with an acetyl bromide/acetic anhydride mixture provides a general and quite simple procedure for the synthesis of N-acetyl-5,6-dihydro-2H-1,2-oxazines. Georg Thieme Verlag Stuttgart.
