100390-66-7

Basic information

• Product Name: N-(2-methoxyphenyl)-N-methyl-3-oxobutanamide
• Synonyms: N-(2-methoxyphenyl)-N-methyl-3-oxobutanamide
• CAS NO: 100390-66-7
• Molecular Weight: 221.256
• Mol File: 100390-66-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-methoxyphenyl)-N-methyl-3-oxobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxyphenyl)-N-methyl-3-oxobutanamide(100390-66-7)
• EPA Substance Registry System: N-(2-methoxyphenyl)-N-methyl-3-oxobutanamide(100390-66-7)

Safety Data

• Hazardous Substances Data: 100390-66-7(Hazardous Substances Data)

Upstream product

• 691-45-2 acetylketene 
• 10541-78-3 2-methoxy-N-methylaniline 
• 674-82-8 4-methyleneoxetan-2-one 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 1374448-07-3 N-methyl-N-(2-methoxyphenyl)-2-diazo-3-oxobutanamide 

Relevant articles and documents

Ruthenium-catalyzed intramolecular cyclization of diazo-β-ketoanilides for the synthesis of 3-alkylideneoxindoles

With [Ru(p-cymene)Cl2]2 as catalyst, diazo-β-ketoanilides would undergo intramolecular carbenoid arene C-H bond functionalization to afford 3-alkylideneoxindoles in up to 92% yields. The reaction occurs under mild conditions and exhibits excellent chemoselectivity. The lack of primary KIE (kH/kD ～ 1) suggests that the reaction should not proceed by rate-limiting C-H bond cleavage; a mechanism involving cyclopropanation of the arene is proposed.