1004-17-7

Basic information

• Product Name: 2-Methylpyrimidine-4-carboxaldehyde
• Synonyms: 2-Methylpyrimidine-4-carboxaldehyde;2-METHYL-PYRIMIDINE-4-CARBALDEHYDE;4-Pyrimidinecarboxaldehyde, 2-methyl- (7CI,8CI,9CI);2-metylpyrimidine-4-carbaldehyde;2-Methyl-4-pyrimidinecarboxaldehyde
• CAS NO: 1004-17-7
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12464
• Product Categories: PYRIMIDINE;Pyrimidine series;Heterocycle-Pyrimidine series
• Mol File: 1004-17-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 213.728 °C at 760 mmHg
• Flash Point: 84.976 °C
• Appearance: /
• Density: 1.176 g/cm³
• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.16±0.23(Predicted)
• CAS DataBase Reference: 2-Methylpyrimidine-4-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylpyrimidine-4-carboxaldehyde(1004-17-7)
• EPA Substance Registry System: 2-Methylpyrimidine-4-carboxaldehyde(1004-17-7)

Safety Data

• Hazardous Substances Data: 1004-17-7(Hazardous Substances Data)

Usage

General Description

2-Methylpyrimidine-4-carboxaldehyde is a chemical compound that is primarily used as a building block for the synthesis of pharmaceuticals and agrochemicals. It is a member of the pyrimidine family of chemicals and has a molecular formula of C6H6N2O. 2-Methylpyrimidine-4-carboxaldehyde is a yellow to brown liquid with a pungent odor and is highly flammable. It is commonly used as an intermediate in the production of various pharmaceuticals, such as antiviral and anticancer drugs, as well as in the synthesis of pesticides and herbicides. Additionally, it has potential applications in the development of new materials and compounds for various industrial and scientific purposes.

InChI:InChI=1/C6H6N2O/c1-5-7-3-2-6(4-9)8-5/h2-4H,1H3

Upstream product

• 175277-33-5 4-(dimethoxymethyl)-2-methylpyrimidine 

Downstream Products

• 878760-44-2 (phenylamino-(2-methyl-pyrimidin-4-yl)-methyl)-phosphonic acid diphenyl ester 
• 1178482-78-4 N-benzyl-1-(2-methyl-4-pyrimidinyl)methanamine 
• 1421236-88-5 (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-2-methyl-1-(2-methylpyrimidin-4-yl)-3-oxopropyl)-2-methylpropane-2-sulfinamide 
• 312262-93-4 3-(2-Methyl-pyrimidin-5-yl)-propenal 

Relevant articles and documents

SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-A]PYRAZIN-1 (2H)-ONE DERIVATIVES AS KINASE INHIBITORS

Compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 have any of the meanings defined hereinbefore in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cancer are disclosed.

Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Pyrimidine analogs of the pyridinylimidazole class of CSBP/p38 kinase inhibitors were prepared in an effort to reduce the potent inhibition of hepatic cytochrome P450 observed for the pyridinyl compounds. The substitution of pyrimidin-4-yl, 2-methoxypyrimidin-4-yl, or 2- methylaminopyrimidin-4-yl for pyridin-4-yl effectively dissociates CSBP/p38 kinase from P450 inhibition for this series and furthermore achieves an increase in oral activity.