10040-45-6 Usage
Description
Sodium picosulfate is a stimulant laxative medication that belongs to the family of contact laxatives. It is an off-white solid with chemical properties that enable it to increase the frequency and force of peristalsis, as well as promote electrolyte and water retention in the colon. This medication is primarily used to treat constipation and is also utilized in the evaluation of the colon by stimulating bowel movements following hydrolysis by colon bacteria.
Uses
Used in Pharmaceutical Industry:
Sodium picosulfate is used as a stimulant laxative for the treatment of constipation. It works by increasing the frequency and force of peristalsis, which helps to move the contents of the colon more quickly and effectively. This results in a more rapid and complete evacuation of the bowel, providing relief for individuals suffering from constipation.
Used in Medical Diagnostics:
In the field of medical diagnostics, sodium picosulfate is used for the evaluation of the colon. It stimulates bowel movements following hydrolysis by colon bacteria, which can be particularly useful in preparing patients for colonoscopies or other diagnostic procedures that require a clear view of the colon's interior. By promoting bowel movements, sodium picosulfate helps to ensure that the colon is clean and free of any obstructions that could interfere with the diagnostic process.
Used in Gastrointestinal Health:
Sodium picosulfate is also used to address gastrointestinal health issues related to constipation. It can be prescribed to patients who experience infrequent or difficult bowel movements, providing relief and improving overall digestive health. Additionally, sodium picosulfate may be used in combination with other medications or treatments to manage more complex gastrointestinal conditions.
Originator
Guttalax, De Angelini, Italy ,1967
Therapeutic Function
Laxative
Check Digit Verification of cas no
The CAS Registry Mumber 10040-45-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,4 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10040-45:
(7*1)+(6*0)+(5*0)+(4*4)+(3*0)+(2*4)+(1*5)=36
36 % 10 = 6
So 10040-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
10040-45-6Relevant articles and documents
Preparation method of sodium picosulfate
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Paragraph 0040; 0043-0045; 0048-0050; 0053-0055; 0058; ..., (2021/09/15)
The invention belongs to the technical field of medicines, and relates to a preparation method of sodium picosulfate, in particular to condensation of pyridine -2 - formaldehyde and phenol under an acidic condition, and the obtained intermediate 4,4 ' - (2 - pyridinmethylene) - bisphenol uses sulfamic acid as a sulfonating agent. The method is relatively simple in process operation and high in sample purity.
A process for preparing sodium new method (by machine translation)
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, (2019/04/30)
The invention relates to a method for preparing (V) indicated by the sodium of the method, the method comprises the following steps: (a) in formula (I) indicated by the 2 - picolinic ester as the starting material, as shown in formula (II) of 4 - halogenated phenyl ether in the formula (III) Grignard reaction indicated by the 4', 4" - dialkoxy diphenyl - (2 - pyridine) - methanol (compound III). (B) 4 ', 4 "- dialkoxy diphenyl - (2 - pyridine) - methanol (compound III) in the Lewis acid under the action of removing a water molecule and alkoxy alkyl, formula (IV) as shown by a 4', 4" - dihydroxy phenyl - (2 - pyridine) - methane (compound IV). (C) 4', 4" - dihydroxy phenyl - (2 - pyridine) - methane with chlorosulfuric acid in sulfuric acid esterification reaction, sodium hydroxide after treatment, to obtain crude sodium, by recrystallization to obtain high-purity sodium (compound V). The present invention provides a kind of existing technology with the different sodium new preparation method, the method is simple in operation, the atom economy is high, is suitable for industrial production. (by machine translation)