1004315-80-3

Basic information

• Product Name: (2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone
• Synonyms: (2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone
• CAS NO: 1004315-80-3
• Molecular Weight: 297.397
• Mol File: 1004315-80-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone(1004315-80-3)
• EPA Substance Registry System: (2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone(1004315-80-3)

Safety Data

• Hazardous Substances Data: 1004315-80-3(Hazardous Substances Data)

Upstream product

• 41489-62-7 1-[3-(benzyloxy)phenyl]-3-(dimethylamino)-2-methylpropan-1-one 
• 37951-47-6 3-benzyloxyphenyl ethyl ketone 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 1004315-81-4 C₁₈H₁₄O₈*C₁₉H₂₃NO₂ 

Downstream Products

• 175591-09-0 tapentadol hydrochloride 
• 1004315-82-5 (2S,3R)-1-(dimethylamino)-3-(3-benzyloxyphenyl)-2-methyl-3-pentanol 
• 175591-23-8 tapentadol 

Relevant articles and documents

A synthetic hydrochloric acid he spurts he number of method

The invention discloses a method for synthesizing tapentadol hydrochloride. The method comprises a reaction route shown in the specification. In the reaction route, R1 is one of halogens, -OH, -OR4, -NO2, -NH2, -NR5R6, -SH and -SR7. A required chiral isomer is directly obtained through a reaction under chiral catalysis, so the method has the advantages of avoiding of problems of a large amount of wastes and environmental protection due to chiral splitting, short route, simple operation, easy industrialization, high raw material utilization rate, great improvement of the yield, cost reduction, meeting of requirements of industrial production of tapentadol hydrochloride, and significant progress.

PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL]PHENOL

The present invention relates to an improved process for the preparation of 3- [(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.