100442-33-9

Basic information

• Product Name: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol
• Synonyms: 2,N-DIMETHYL-N-(3,3-DIPHENYLPROPYL)-1-AMINO-2-PROPANOL;1-(3,3-DIPHENYL-N-METHYLPROPYLAMINO)-2-METHYL-2-PROPANOL;1-[(3,3-Diphenylpropyl)methylamino]-2-methyl-2-propanol ;2,N-Dimethyl-N-(3,3-Diphenylpr;1-(3,3-diphenyl-N-methylpropylamino)-2-methyl-2-propanol (intermediate of lercanidipine);2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol (intermediate of lercanidipine);2,N-DIMEHYL-n(3,3-DIPHENYLPROPYL)-1-amino-2-propanol;LERCANIDIPINEBRANCH
• CAS NO: 100442-33-9
• Molecular Formula: C₂₀H₂₇NO
• Molecular Weight: 297.43
• EINECS: 239-349-0
• Product Categories: Chemical intermediate for Lercanidipine;Amines;(intermediate of lercanidipine);Chemical Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Lercanidipine Hydrochloride;Lercanidipine intermediate
• Mol File: 100442-33-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 145°C/0.2mmHg(lit.)
• Flash Point: 164.7 °C
• Appearance: slightly brown liquid
• Density: 1.025 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5430 to 1.5470
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.90±0.29(Predicted)
• Stability: Normal temperature and pressure
• CAS DataBase Reference: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol(100442-33-9)
• EPA Substance Registry System: 2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol(100442-33-9)

Safety Data

• Hazardous Substances Data: 100442-33-9(Hazardous Substances Data)

Usage

Description

2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol is an organic compound with a complex molecular structure. It is characterized by its slightly brown liquid appearance and is primarily used as an intermediate in the synthesis of the pharmaceutical drug Lercanidipine.

Uses

Used in Pharmaceutical Industry:
2,N-Dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol is used as a key intermediate in the synthesis of Lercanidipine for its role in the development of antihypertensive medications. As a component in the production process, it contributes to the creation of drugs that help manage high blood pressure and related cardiovascular conditions.
Used as Lercanidipine Intermediate:
The compound serves a crucial function in the chemical synthesis of Lercanidipine, a dihydropyridine calcium channel blocker. It is utilized in the pharmaceutical industry to produce medications that are effective in treating hypertension and angina pectoris by relaxing blood vessel walls and improving blood flow.

InChI:InChI=1/C20H27NO/c1-20(2,22)16-21(3)15-14-19(17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-13,19,22H,14-16H2,1-3H3

Upstream product

• 558-42-9 3-chloro-2-methylpropan-2-ol 
• 28075-29-8 N-methyl-3,3-diphenylpropylamine 

Downstream Products

• 100427-51-8 1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate 
• 100427-26-7 lercanidipine 
• 132866-11-6 lercanidipine hydrochloride 
• 786625-22-7 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl} ester 5-ethyl ester 
• 210579-45-6 2-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-[(3,3-diphenyl-propyl)-methyl-amino]-1,1-dimethyl-ethyl ester 

Relevant articles and documents

Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity

A series of asymmetric 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates characterized by the presence of a 3,3-diphenylpropylamino moiety in one of the ester groups were synthesized. They exhibited remarkable antihypertensive activity in spontaneously hypertensive rats as well as affinity for the 1,4- dihydropyridines binding site labelled by 3H-nitrendipine in the calcium channel. Introduction of this bulky and lipophilic amine confers to the whole series an elevated level of antihypertensive activity and a long duration of action, a structure-dependent modulation of the activity being found only in the subset characterized by the presence of a branched propylene bridge between the ester and the amino groups. The presence of the amino group is essential for oral activity. Out of this series, compound 9u (Rec 15/2375- lercanidipine) was selected for clinical development and obtained marketing authorization as an antihypertensive in several countries.