10049-60-2

Basic information

• Product Name: sec-butylammonium chloride
• Synonyms: sec-butylammonium chloride;2-AMINOBUTANE HYDROCHLORIDE;sec-butylamine hydrochloride;butan-2-amine hydrochloride
• CAS NO: 10049-60-2
• Molecular Formula: C₄H₁₂N*Cl
• Molecular Weight: 109.59778
• EINECS: 233-176-4
• Mol File: 10049-60-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 152-153 °C
• Boiling Point: 62.9°Cat760mmHg
• Flash Point: 25.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 175mmHg at 25°C
• CAS DataBase Reference: sec-butylammonium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: sec-butylammonium chloride(10049-60-2)
• EPA Substance Registry System: sec-butylammonium chloride(10049-60-2)

Safety Data

• Hazardous Substances Data: 10049-60-2(Hazardous Substances Data)

Usage

General Description

Sec-butylammonium chloride is a quaternary ammonium salt with the formula (CH3)3CCH2NH3Cl. It is a white, crystalline solid that is commonly used as a phase-transfer catalyst in organic synthesis. sec-butylammonium chloride is prepared by reacting sec-butylamine with hydrochloric acid. It is soluble in water and other polar solvents, and its ability to transfer cations across immiscible phases makes it useful in a variety of chemical reactions. Sec-butylammonium chloride is also used as an intermediate in the production of pharmaceuticals and agrochemicals and as an ingredient in some specialty reagents for analytical chemistry. It is important to handle this compound with care, as it is a mild irritant to the skin, eyes, and respiratory system.

InChI:InChI=1/C4H11N.ClH/c1-3-4(2)5;/h4H,3,5H2,1-2H3;1H

Upstream product

• 2719-08-6 methyl 2-(acetylamino)benzoate 
• 142310-24-5 1-<(1-methylpropylidene)amino>-3-phenyl-4-methyl-5-methoxypyrazole 
• 102095-57-8 C₁₃H₂₈NO₅P 
• 76716-18-2 diphenylphosphinic 1-methylpropylamide 
• 146039-14-7 sec-Butyl-phosphorimidic acid triethyl ester 

Downstream Products

• 513-49-5 (S)-2-aminobutane 
• 556-02-5 tyrosine 
• 78-93-3 butanone 
• 673-06-3 D-(R)-phenylalanine 
• 640-68-6 D-Val-OH 
• 31458-26-1 N-sec-Butyl-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 81038-91-7 3-sec-butylamino-1,2-benzisothiazole-1,1-dioxide 
• 83325-08-0 1,7-dihydro-2-methyl-1-(1-methylpropyl)-7-phenyl-6H-purin-6-one 
• 86217-79-0 sec-butyl isocyanate 

Relevant articles and documents

Hydrogenolysis of 1-Aminopyrazoles: Synthesis of Primary and Secondary Alkylamines

The tautomerizable N-aminopyrazolone 9, the O-methyl 1 and N-methyl derivatives 4 were condensed with carbonyl compounds to give the alkenylaminopyrazoles 12, 2a-g and 5c, wich, under mild conditions, were hydrogenated to the corresponding alkylamino derivatives.The subesquent hydrogenation of the latter ones gave different results according to the structure of the starting material.The 5-methoxy-1-alkylaminopyrazoles 3a-g yielded the 5-methoxypyrazole 15 and the corresponding primary amines in good yields.On the contrary, N-methyl-1-alkylaminopyrazolone-5 6c gave 1-a lkylpyrazolone-3 8.

Conversion of Alcohols into Primary Amines, a New Mitsunobu Version of Gabriel-type Synthesis

Primaere und sekundaere Alkohole liefern die entsprechenden Amin-hydrochloride 3 mit guten Ausbeuten (60-85percent), wenn sie unter milden Bedingungen mit N-(Diethoxyphosphoryl)-carbamidsaeure-tert-butylester (1) in Gegenwart von Azodicarbonsaeure-diethylester/Triphenylphosphan umgesetzt und danach die entstandenen N-Alkyl-N-(diethoxyphosphoryl)carbamidsaeureester 2 mit gasfoermigem HCl gespalten werden.Die Stereochemie dieser Reaktion wird untersucht.

Phosphoramides. XIII. Phosphorus Pentaoxide-Amine Hydrochloride Mixtures as Reagents in the Synthesis of 4(3H)-Quinazolinones and 4-Quinazolinamines

4(3H)-Quinazolinones 3a-r have been prepared by heating methyl N-acylanthranilates 1a-c and the hydrochlorides of primary aliphatic and aromatic amines with phosphorus pentaoxide and N,N-dimethylcyclohexylamine at 180 deg C. 4-Quinazolinamines 4 and the amidine 7 were isolated as by-products.The carboxamides 5 and 6 were believed to be reaction intermediates.By raising the temperature to 250 deg C 4 was obtained in a preparative yield.