100492-07-7

Basic information

• Product Name: 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, ethyl ester
• CAS NO: 100492-07-7
• Molecular Formula: C22H21F3N4O3
• Molecular Weight: 446.429
• Mol File: 100492-07-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, ethyl ester(100492-07-7)
• EPA Substance Registry System: 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, ethyl ester(100492-07-7)

Safety Data

• Hazardous Substances Data: 100492-07-7(Hazardous Substances Data)

Upstream product

• 100490-99-1 ethyl-3,1-(2,4-difluoroanilino)-2-(2,6-dichloro-5-fluoronicotinyl) acrylate 
• 82671-03-2 ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 
• 96568-02-4 2,6-dichloro-5-fluoro-3-nicotinoyl chloride 
• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 
• 109-01-3 1-methyl-piperazine 
• 100491-29-0 ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Downstream Products

• 104051-68-5 1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; hydrochloride 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of New Arylfluoronaphthyridine Antibacterial Agents

Novel arylfluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid have been prepared and their antibacterial activity evaluated.These derivatives are characterized by having a fluorine atom at 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or o,p-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (38) was found to possess excellent in vitro potency and in vivo efficacy.