1005031-48-0Relevant articles and documents
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity
Hughes, Terry V.,Xu, Guozhang,Wetter, Steven K.,Connolly, Peter J.,Emanuel, Stuart L.,Karnachi, Prabha,Pollack, Scott R.,Pandey, Niranjan,Adams, Mary,Moreno-Mazza, Sandra,Middleton, Steven A.,Greenberger, Lee M.
, p. 4896 - 4899 (2008)
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2 kinase dependent cell lines will be discussed.
