100516-71-0 Usage
General Description
2-Thiazolecarbonitrile, 5-methyl- is a chemical compound with the molecular formula C5H4N2S. It is a member of the thiazole family of heterocyclic compounds and contains a nitrile functional group. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals, due to its potential medicinal and biological activities. It may also be used in the manufacture of other organic compounds, such as dyes and pigments. 2-Thiazolecarbonitrile, 5-methyl- has a characteristic odor and is a yellow to brownish liquid at room temperature, with a high melting point. It is important to handle this chemical with care, as it may be hazardous if not used properly.
Check Digit Verification of cas no
The CAS Registry Mumber 100516-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,5,1 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 100516-71:
(8*1)+(7*0)+(6*0)+(5*5)+(4*1)+(3*6)+(2*7)+(1*1)=70
70 % 10 = 0
So 100516-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N2S/c1-4-3-7-5(2-6)8-4/h3H,1H3
100516-71-0Relevant articles and documents
Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates
Reiner, John E.,Siev, Daniel V.,Araldi, Gian-Luca,Cui, Jingrong Jean,Ho, Jonathan Z.,Reddy, Komandla Malla,Mamedova, Lala,Vu, Phong H.,Lee, Kuen-Shan S.,Minami, Nathaniel K.,Gibson, Tony S.,Anderson, Susanne M.,Bradbury, Annette E.,Nolan, Thomas G.,Semple, J. Edward
, p. 1203 - 1208 (2007/10/03)
Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.
