1005402-80-1Relevant articles and documents
4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists
Hudkins, Robert L.,Aimone, Lisa D.,Dandu, Reddeppa Reddy,Dunn, Derek,Gruner, John A.,Huang, Zeqi,Josef, Kurt A.,Lyons, Jacquelyn A.,Mathiasen, Joanne R.,Tao, Ming,Zulli, Allison L.,Raddatz, Rita
, p. 194 - 198 (2012/03/10)
H3R structure-activity relationships for a new class of 4,5-dihydropyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modification of the 4,5-dihydropyridazinone moiety to block in vivo metabolism identified 4,4-dimethyl