1005770-60-4

Basic information

• Product Name: N-(5-methyl-2-oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-benzamide
• Synonyms: N-(5-methyl-2-oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-benzamide
• CAS NO: 1005770-60-4
• Molecular Weight: 301.42
• Mol File: 1005770-60-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(5-methyl-2-oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-methyl-2-oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-benzamide(1005770-60-4)
• EPA Substance Registry System: N-(5-methyl-2-oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-benzamide(1005770-60-4)

Safety Data

• Hazardous Substances Data: 1005770-60-4(Hazardous Substances Data)

Upstream product

• 554-01-8 5-methylcytosin 
• 75-77-4 chloro-trimethyl-silane 
• 126354-30-1 N-(5-methyl-2-oxo-1H-pyrimidin-4-yl)benzamide 
• 98-88-4 benzoyl chloride 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 1028310-75-9 N-[1-((2R,5S)-3-Fluoro-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 405238-93-9 5-methyl-1-(2,3-dideoxy-2-fluoro-α-D-glycero-pent-2-enofuranosyl)cytosine 
• 405238-94-0 5-methyl-1-(2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl)cytosine 
• 405238-89-3 5-methyl-1-[5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl]-N⁴-benzoylcytosine 
• 405238-90-6 5-methyl-1-[5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-α-D-glycero-pent-2-enofuranosyl]-N⁴-benzoylcytosine 

Relevant articles and documents

Probing Synergistic Effects of DNA Methylation and 2′-β-Fluorination on i-Motif Stability

The possible role of DNA i-motif structures in telomere biology and in the transcriptional regulation of oncogene promoter regions is supported by several recent studies. Herein we investigate the effect of four cytidine nucleosides (and combinations thereof) on i-motif structure and stability, namely 2′-deoxycytidine (dC), 2′-deoxy-5-methyl-cytidine (5-Me-dC), 2′-deoxy-2′-fluoro-arabinocytidine (2′F-araC), and 2′-deoxy-2′-fluoro-5-methyl-arabinocytidine (5-Me-2′F-araC). The base pair 5-Me-2′F-araC:2′F-araC produced i-motifs with a pH1/2 (“pKa”) value that closely matches physiological pH (7.34±0.3). NMR analysis of the most stable telomeric sequence (HJ-2) at pH 7.0 indicated that the structure is stabilized by hybrid 5-Me-dC:2′F-araC hemiprotonated base pairs and therefore highlights the significance of the interplay between base and sugar modifications on the stability of i-motif structures.