1005840-44-7Relevant articles and documents
Large neutral amino acid transporter enables brain drug delivery via prodrugs
Gynther, Mikko,Laine, Krista,Ropponen, Jarmo,Lepp?nen, Jukka,Mannila, Anne,Nevalainen, Tapio,Savolainen, Jouko,J?rvinen, Tomi,Rautio, Jarkko
, p. 932 - 936 (2008/09/19)
The blood-brain barrier efficiently controls the entry of drug molecules into the brain. We describe a feasible means to achieve carrier-mediated drug transport into the rat brain via the specific, large neutral amino acid transporter (LAT1) by conjugatin