1006-34-4

Basic information

• Product Name: 2-Bromo-5-fluorobenzamide
• Synonyms: Benzamide, 2-bromo-5-fluoro-
• CAS NO: 1006-34-4
• Molecular Formula: C₇H₅BrFNO
• Molecular Weight: 218.02
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 1006-34-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 249.8°C at 760 mmHg
• Flash Point: 104.9°C
• Appearance: /
• Density: 1.696g/cm³
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-5-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluorobenzamide(1006-34-4)
• EPA Substance Registry System: 2-Bromo-5-fluorobenzamide(1006-34-4)

Safety Data

• Hazardous Substances Data: 1006-34-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-fluorobenzamide is a chemical compound with the molecular formula C7H5BrFNO. It is a derivative of benzamide, and it contains a bromine atom and a fluorine atom on the benzene ring. 2-Bromo-5-fluorobenzamide has various applications in organic and medicinal chemistry, including as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It may also be used as a reagent in chemical reactions or as a building block for the creation of more complex organic molecules. Additionally, 2-Bromo-5-fluorobenzamide has potential biological and pharmacological activities, which make it a subject of interest for researchers studying its potential use in drug discovery and development.

InChI:InChI=1/C7H5BrFNO/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H2,10,11)

Upstream product

• 57381-39-2 2-bromo-5-fluorobenzonitrile 
• 33184-16-6 5-fluoro-2-methylbenzoic acid 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 111771-13-2 2-bromo-4-fluorobenzoyl chloride 

Downstream Products

• 1021539-61-6 C₂₆H₂₁F₂N₃O₂ 
• 1207252-46-7 5-fluoro-2-(hex-1-ynyl)benzamide 
• 1338797-90-2 5-fluoro-2-(phenylethynyl)benzamide 
• 1425605-66-8 5-fluoro-2-((4-methoxyphenyl)ethynyl)benzamide 
• 1425605-95-3 7-fluoro-3-phenylisoquinolin-1-amine 
• 1425606-02-5 7-fluoro-3-(4-methoxyphenyl)isoquinolin-1-amine 
• 371945-79-8 6-fluoro-2-phenyl-3H,4H-quinazolin-4-one 
• 1255775-75-7 5-fluoro-2-(5-hydroxypent-1-ynyl)benzamide 
• 67-56-1 methanol 

Relevant articles and documents

Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold

The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.

Synthesis of 1-aminoisoquinolines by gold(III)-mediated domino reactions from 2-alkynylbenzamides and ammonium acetate

A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes plac

2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS

The present invention is directed to 2- [l-phenyl-5 -hydroxy or methoxy-4alpha- methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives of formula I (I) as glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflamma