1006-39-9

Basic information

• Product Name: 2'-BROMO-4'-FLUOROACETOPHENONE
• Synonyms: 2'-Bromo-4'-fluoroacetophenone 97%;2'-Bromo-4'-fluoroacetophenone97%;2'-Bromo-4'-Fluoroacetophenone;2'-Bromo-4'-fluoroacetophenone;1-Acetyl-2-bromo-4-fluorobenzene;1-(2-broMo-4-fluorophenyl)ethan-1-one;1-(2-BroMo-4-fluorophenyl)ethanone;Ethanone,1-(2-bromo-4-fluorophenyl)-
• CAS NO: 1006-39-9
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.04
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);Benzene series;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Aromatics;Miscellaneous Reagents
• Mol File: 1006-39-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 48-50°C
• Boiling Point: 150°C 12mm
• Flash Point: 110°C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Refrigerator
• BRN: 2249797
• CAS DataBase Reference: 2'-BROMO-4'-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-BROMO-4'-FLUOROACETOPHENONE(1006-39-9)
• EPA Substance Registry System: 2'-BROMO-4'-FLUOROACETOPHENONE(1006-39-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• Hazardous Substances Data: 1006-39-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

InChI:InChI=1/C8H6BrFO/c1-5(11)7-3-2-6(10)4-8(7)9/h2-4H,1H3

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 108-24-7 acetic anhydride 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 261711-20-0 1-(2-bromo-4-fluorophenyl)ethan-1-ol 
• 289038-17-1 (E)-3-(2-bromo-4-fluorophenyl)acrylic acid 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 75-16-1 methylmagnesium bromide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 7789-45-9 copper(II)bromide 

Downstream Products

• 51788-87-5 2-bromo-4-fluoro-1-(prop-1-en-2-yl)benzene 
• 251367-42-7 1-(2-oxo-2-phenylethyl)-2-chloro-5-[(E)-1-phenyl-2-methylcarbamoylvinyl]pyridinium iodide 
• 251367-44-9 1-[2-oxo-2-(4-fluorophenyl)ethyl]-2-chloro-5-[(E)-1-phenyl-2-methylcarbamoylvinyl]pyridinium iodide 
• 261711-20-0 1-(2-bromo-4-fluorophenyl)ethan-1-ol 
• 1203608-46-1 (E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one 
• 1286202-68-3 C₁₀H₁₂BrFO₂ 
• 1255708-30-5 C₁₈H₂₃BrN₂O₃ 
• 1261497-12-4 1-(4-amino-2-bromophenyl)ethan-1-one 
• 1329166-62-2 [3-bromo-4-(2-bromo-acetyl)-phenyl]-carbamic acid methyl ester 
• 1329166-63-3 (4-acetyl-3-bromo-phenyl)-carbamic acid methyl ester 
• 1241898-33-8 2-bromo-4-fluoro-1-(1-methylcyclopropyl)benzene 
• 594810-90-9 2-bromo-1-(2-bromo-4-fluorophenyl)ethan-1-one 

Relevant articles and documents

Intramolecular One-Carbon Homologation of Unstrained Ketones via C-C Activation-Enabled 1,1-Insertion of Alkenes

Here, we describe the development of a Rh-catalyzed intramolecular one-carbon homologation of unstrained aryl ketones through a formal 1,1-insertion process of olefins, enabled by temporary directing group (TDG)-aided C-C activation. The reaction provides a distinct approach to access various substituted 1-indanones. Computational mechanistic studies reveal that the formal 1,1-insertion is realized by a selective C(sp2)-C(sp3) activation and turnover limiting 2,1-insertion into the alkene, followed by a facile β-H elimination and reinsertion process.

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

Divergent Access to Benzocycles through Copper-Catalyzed Borylative Cyclizations

A copper-catalyzed chemodivergent approach to five- and six-membered benzocycles from dienyl arenes tethered with a ketone has been developed. Through proper choice of coordinating ligands and catalytic conditions, copper-catalyzed borylative cyclization of a single dienyl arene can be diverted to two different pathways, leading to indanols and dihydronaphthalenols with high stereoselectivity. The chiral bidentate bisphosphine ligand (S,S)-Ph-BPE was optimal for asymmetric copper-allyl addition to a tethered ketone via a boat-like transition state, whereas NHC ligands led to boro-allyl addition producing indanols with high diastereoselectivity. (Figure presented.).