1006055-69-1Relevant articles and documents
A Diels-Alder approach to biaryls (DAB): synthesis of the western portion of TMC-95
Ashburn, Bradley O.,Rathbone, Lauren K.,Camp, Elizabeth H.,Carter, Rich G.
, p. 856 - 865 (2008/09/16)
The rapid synthesis of the western biaryl portion of TMC-95 is disclosed via the use of a Diels-Alder reaction with o-nitrostyrene derivative and 1-silyloxy diene with excellent regiochemical control. Subsequent sequential substitutions of a p-iodo-phenol