100627-39-2Relevant articles and documents
Stereochemistry of N-Benzoyl-5-substituted-1-benzazepines Revisited: Synthesis of the Conformationally Biased Derivatives and Revision of the Reported Structure
Tabata, Hidetsugu,Yoneda, Tetsuya,Tasaka, Tomohiko,Ito, Shigekazu,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
, p. 3136 - 3148 (2016)
The syn (aR?,5R?) and anti (aS?,5R?) diastereomers of N-benzoyl-C5-substituted-1-benzazepines originating in the chiralities at C5 and the Ar-N(C=O) axis were first stereoselectively synthesized by biasing the conformation with a substituent at C6 and C9, respectively. Detailed examination of the stereochemistry (i.e., conformation and configuration) of these N-benzoyl-1-benzazepines by X-ray crystallographic analysis, VT NMR, and DFT calculations revealed new physicochemical aspects of these heterocycles including revision of the stereochemistry previously reported.
VASOPRESSIN V1A ANTAGONISTS
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Page/Page column 32-33, (2008/06/13)
The present invention concerns compounds inter alia according to general formula 1a. Compounds according to the invention are vasopressin V 1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment of dysmenorrhoea.