1006442-51-8 Usage
Description
1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole is a chemical compound characterized by its molecular formula C5H5F2N3O2. It is a nitro-substituted pyrazole derivative that features fluorine and nitro groups, which contribute to its reactivity and potential applications in organic synthesis. 1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole is primarily utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and its unique structure and properties may also offer potential applications in the fields of medicinal chemistry and agrochemical development. However, due to its potential toxicity and reactivity, it is crucial to handle this compound with caution.
Uses
Used in Pharmaceutical Synthesis:
1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure, which includes difluoroethyl and nitro groups, allows for the creation of a wide range of pharmaceutical compounds with different therapeutic properties.
Used in Agrochemical Development:
In the agrochemical industry, 1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole is employed as an intermediate in the development of agrochemicals. Its reactivity and the presence of functional groups make it a valuable component in the synthesis of compounds used in agriculture for pest control, crop protection, and other related applications.
Used in Medicinal Chemistry:
1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole may have potential applications in medicinal chemistry due to its unique structure and properties. Researchers can leverage its reactivity to design and synthesize novel compounds with potential therapeutic effects for various medical conditions.
Used in Organic Synthesis:
1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole is also used in organic synthesis, where its difluoroethyl and nitro groups can be exploited to create a variety of organic molecules with different functionalities and applications across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1006442-51-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,6,4,4 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1006442-51:
(9*1)+(8*0)+(7*0)+(6*6)+(5*4)+(4*4)+(3*2)+(2*5)+(1*1)=98
98 % 10 = 8
So 1006442-51-8 is a valid CAS Registry Number.
1006442-51-8Relevant articles and documents
N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
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Page/Page column 61, (2021/04/30)
The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R3, and R4, are as defined herein, which are potent inhib
SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS
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Paragraph 0899, (2019/07/13)
The present disclosure relates to compounds of Formula (I): (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
Design and synthesis of novel pyrimidine analogs as highly selective, non-covalent BTK inhibitors
Kawahata, Wataru,Asami, Tokiko,Irie, Takayuki,Sawa, Masaaki
, p. 145 - 151 (2017/12/06)
BTK is a promising target for the treatment of multiple diseases such as B cell malignances, asthma, and rheumatoid arthritis. Here, we report the discovery of a series of novel pyrimidine analogs as potent, highly selective, non-covalent inhibitors of BTK. Compound 25d demonstrated higher affinity to an unactivated conformation of BTK that resulted in an excellent kinase selectivity. Compound 25d showed a good oral bioavailability in mice, and significantly inhibits the PCA reaction in mice.
