100753-43-3

Basic information

• Product Name: (2E)-1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
• Synonyms: 2-propen-1-one, 1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-, (2E)-
• CAS NO: 100753-43-3
• Molecular Formula: C₁₉H₂₀O₅
• Molecular Weight: 328.3591
• Mol File: 100753-43-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 509.2°C at 760 mmHg
• Flash Point: 224.5°C
• Density: 1.148g/cm³
• Vapor Pressure: 1.74E-10mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: (2E)-1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one(100753-43-3)
• EPA Substance Registry System: (2E)-1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one(100753-43-3)

Safety Data

• Hazardous Substances Data: 100753-43-3(Hazardous Substances Data)

Usage

General Description

(2E)-1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one is a chemical compound with a complex molecular structure. It belongs to the class of compounds known as chalcones, which are important intermediates in the synthesis of a variety of biologically active natural products and pharmaceuticals. This particular compound is characterized by its two aromatic rings, each with two methoxy groups attached, and a propenone group that serves as the backbone of the molecule. The compound has potential applications in the fields of medicine, agriculture, and materials science due to its unique structure and chemical properties.

Upstream product

• 67756-04-1 1-(2,4-dimethoxy-phenyl)-prop-2-en-1-one 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 829-20-9 2',4'-dimethoxyacetophenone 

Downstream Products

• 1417453-15-6 C₂₁H₂₇NO₅S 
• 10493-06-8 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one 
• 98508-55-5 1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)prop-1-ene 
• 100753-46-6 1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propan-1-ol 
• 34000-39-0 homobutein 
• 57601-14-6 2'-hydroxy-3,4,4'-trimethoxychalcone 
• 487-52-5 butein 
• 104236-79-5 (E)-1-(2,4-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-prop-2-en-1-one 
• 125966-81-6 <4,6-bis(2',4',3,4-tetramethoxyphenyl)>pyrimidine-2-sulphonamido-N⁴-acetamide 
• 100753-44-4 1-(2,4-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)propan-1-one 

Relevant articles and documents

Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives

Carbonic anhydrases (CA, EC 4.2.1.1) are Zinc metalloenzymes and are present throughout most living organisms. Among the catalytically active isoforms are the cytosolic CA I and II, and tumor-associated CA IX and CA XII. The carbonic anhydrase (CA) inhibitory activities of newly synthesized pyrazoline-linked benzenesulfonamides 18–33 against human CA (hCA) isoforms I, II, IX, and XII were measured and compared with that of acetazolamide (AAZ), a standard inhibitor. Potent inhibitory activity against hCA I was exerted by compounds 18–25, with inhibition constant (KI) values of 87.8–244.1 nM, which were greater than that of AAZ (KI, 250.0 nM). Compounds 19, 21, 22, 29, 30, and 32 were proven to have inhibitory activities against hCA IX with KI values (5.5–37.0 nM) that were more effective than or nearly equal to that of AAZ (KI, 25.0 nM). Compounds 20–22, and 30 exerted potent inhibitory activities (KIs, 7.1–10.1 nM) against hCA XII, in comparison with AAZ (KI, 5.7 nM).

Hydroxyaurone derivative as well as preparation method and application thereof

The invention relates to a hydroxyaurone derivative as well as a preparation method and application thereof. A monomeric compound aurone separated from Kunlun chrysanthemum in Xinjiang is used as a mother nucleus compound, hydroxyl is introduced into auro

NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).