1007556-16-2

Basic information

• Product Name: N-benzyl-9-butyl-2-chloro-9H-purin-6-amine
• Synonyms: N-benzyl-9-butyl-2-chloro-9H-purin-6-amine
• CAS NO: 1007556-16-2
• Molecular Weight: 315.805
• Mol File: 1007556-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyl-9-butyl-2-chloro-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-9-butyl-2-chloro-9H-purin-6-amine(1007556-16-2)
• EPA Substance Registry System: N-benzyl-9-butyl-2-chloro-9H-purin-6-amine(1007556-16-2)

Safety Data

• Hazardous Substances Data: 1007556-16-2(Hazardous Substances Data)

Upstream product

• 5451-40-1 2,6 dichloropurine 
• 502184-58-9 9-butyl-2,6-dichloro-9H-purine 
• 100-46-9 benzylamine 
• 109-65-9 1-bromo-butane 
• 39639-47-9 N⁶-benzyl-2-chloroadenine 

Downstream Products

• 1007555-37-4 C₁₇H₁₈N₆ 

Relevant articles and documents

Synthesis and pharmacophore modelling of 2,6,9-trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines

Twelve compounds were obtained by a three step synthetic procedure using microwave irradiation in a pivotal step. All compounds were evaluated in vitro to determine their potential effect on cell toxicity by the MTT method and flow cytometry analysis on four cancer cells lines and Vero cells. Three out of twelve compounds were found to be promising agents compared to a known and effective anticancer drug, etoposide, in three out of four cancer cell lines assayed with considerable selectivity. Preliminary flow cytometry data suggests that compounds mentioned above induce apoptosis on these cells. The main structural requirements for their activity for each cancer cell line were characterized with a preliminary pharmacophore model, which identified aromatic centers, hydrogen acceptor/donor center and a hydrophobic area. These features were consistent with the cytotoxic activity of the assayed compounds.