100777-49-9

Basic information

• Product Name: 2-(3-methoxy-4-nitrophenylthio)ethanol
• Synonyms: 2-(3-methoxy-4-nitrophenylthio)ethanol
• CAS NO: 100777-49-9
• Molecular Weight: 229.257
• Mol File: 100777-49-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(3-methoxy-4-nitrophenylthio)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methoxy-4-nitrophenylthio)ethanol(100777-49-9)
• EPA Substance Registry System: 2-(3-methoxy-4-nitrophenylthio)ethanol(100777-49-9)

Safety Data

• Hazardous Substances Data: 100777-49-9(Hazardous Substances Data)

Usage

Appearance

Colorless to pale yellow liquid This describes the physical appearance of the compound in its pure form.

Molecular weight

253.25 g/mol This is the mass of one mole of the compound, which helps determine its molar concentration in various applications.

Uses as a coupling agent

Synthesis of dyes 2-(3-methoxy-4-nitrophenylthio)ethanol is used to join two chemical groups together, specifically in the production of dyes.

Uses as a building block

Production of pharmaceuticals and other organic compounds This compound serves as a fundamental component in the creation of various pharmaceuticals and organic compounds.

Application as a reagent

Organic synthesis 2-(3-methoxy-4-nitrophenylthio)ethanol is used as a reactant in organic synthesis, aiding in the formation of new chemical bonds and structures.
7. Application in the manufacture of fragrances and flavorings The compound is used as a starting material or intermediate in the production of various fragrances and flavorings.

Potential applications

Medicine, agriculture, and industry Due to its diverse chemical properties and reactivity, the compound has potential uses in a wide range of fields.

Hazardous if not properly managed

Caution required Handling and disposal of 2-(3-methoxy-4-nitrophenylthio)ethanol should be done with care, as it may pose risks to human health and the environment if not managed correctly.

Upstream product

• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 623-51-8 ethyl 2-sulfanylacetate 
• 60-24-2 2-hydroxyethanethiol 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 

Downstream Products

• 1291106-98-3 3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate 
• 1291106-94-9 C₁₈H₂₉N₃O₃S 
• 1291106-95-0 C₁₂H₁₉N₃OS 
• 1291106-96-1 C₂₁H₂₃ClF₃N₃O₃S 
• 1291106-97-2 C₂₂H₂₁ClF₃N₃O₄S 
• 1291106-72-3 C₂₂H₂₁ClF₃N₃O₅S 
• 1291106-73-4 C₂₂H₂₁ClF₃N₃O₅S 

Relevant articles and documents

Fragment-based modification of 2,4-diarylaminopyrimidine derivatives as ALK and ROS1 dual inhibitors to overcome secondary mutants

In order to explore novel ALK and ROS1 dual inhibitors capable of overcoming crizotinib-resistant mutants, two series of 2,4-diarylaminopyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxic activity. In this work, we retained the 2,4-diarylaminopyrimidine scaffold and derivatize the DAAP scaffold with sulfonyl and acrylamide moieties to extend the structure–activity relationship (SAR) study. To our delight, some compounds exhibited excellent inhibitory activity with a double-digit nanomolar level in MTT assay. Four compounds were selected for enzymic assays further, the results led to the identification of a potent ALK and ROS1 dual inhibitor X-17, with IC50 values of 3.7 nM, 2.3 nM, 8.9 nM and 1.9 nM against ALK, ALKL1196M, ALKG1202R and ROS1, respectively. Ultimately, the molecular docking studies on X-17 clearly disclosed reasonable and optimal binding interactions with ALK.

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

SULFOXIDE DERIVATIVES FOR THE TREATMENT OF TUMORS

Sulfoxide derivatives of the formula Ia to Im as described, and pharmaceutically usable salts, solvates, enantiomers, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for the treatment of tumours.