100792-27-6

Basic information

• Product Name: 3-bromo-4-heptyloxybenzaldehyde
• Synonyms: 3-bromo-4-heptyloxybenzaldehyde
• CAS NO: 100792-27-6
• Molecular Weight: 299.208
• Mol File: 100792-27-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-4-heptyloxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-4-heptyloxybenzaldehyde(100792-27-6)
• EPA Substance Registry System: 3-bromo-4-heptyloxybenzaldehyde(100792-27-6)

Safety Data

• Hazardous Substances Data: 100792-27-6(Hazardous Substances Data)

Upstream product

• 629-04-9 1-Bromoheptane 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 

Relevant articles and documents

Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1 H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors

Xanthine oxidase is a key enzyme that catalyses hypoxanthine and xanthine to uric acid, whose overproduction leads to the gout-causing hyperuricemia. In this study, a series of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives (4ae4k and 6ae6k) was synthesized and evaluated for their inhibitory potency against xanthine oxidase. The 1-hydroxyl substituted derivatives 4ae4k showed excellent inhibitory potency with IC50 values ranging from 0.003 μM to 1.2 μM, with compounds 4d (IC50= 0.003 μM), 4e (IC50 = 0.003 μM), and 4f (IC50 = 0.006 μM) manifesting the most potent xanthine oxidase inhibitory potency that were comparable with that of Febuxostat (IC50 = 0.01 μM). LineweavereBurk plot analysis revealed that representative compound 4f acted as a mixed-type inhibitor for xanthine oxidase. The basis of significant inhibition of xanthine oxidase by 4f was rationalized by its molecular docking into the active site of xanthine dehydrogenase.