100814-63-9

Basic information

• Product Name: 5,5-Difluoro-4-hydroxy-6-imino-tetrahydro-pyrimidin-2-one
• Synonyms: 5,5-Difluoro-4-hydroxy-6-imino-tetrahydro-pyrimidin-2-one
• CAS NO: 100814-63-9
• Molecular Weight: 165.099
• Mol File: 100814-63-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,5-Difluoro-4-hydroxy-6-imino-tetrahydro-pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-Difluoro-4-hydroxy-6-imino-tetrahydro-pyrimidin-2-one(100814-63-9)
• EPA Substance Registry System: 5,5-Difluoro-4-hydroxy-6-imino-tetrahydro-pyrimidin-2-one(100814-63-9)

Safety Data

• Hazardous Substances Data: 100814-63-9(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 71-30-7 cytosine 

Relevant articles and documents

Mechanism and Stereochemistry of the luorination of Uracil and Cytosine Using Fluorine and Acetyl Hypofluorite

The products of the reaction of CH3COOF and F2 with uracil and cytosine dissolved in acetic acid and water were studied by using 18F as a tracer.Apart from 5-fluorouracil (2) and the 5,5-difluoro adducts 5a and 5b, the 1H NMR spectra of the crude reaction mixture showed the presence of two geometric isomers of both 5- fluoro-6-acetoxy-5,6-dihydrouracil (3a, 4a) and 5-fluoro-6-hydroxy-5,6-dihydrouracil (3b, 4b).In the fluorination of cytosine, corresponding products were observed with the exception of the acetoxy adducts.For both reagents and for both substrates a radical-cation mechanism is proposed.The observed conversions of the acetoxy adducts of uracil are explained by an acylimine (iii) as an intermediary.