1008303-73-8

Basic information

• Product Name: (2,3-diphenyl-indol-1-yl)(piperidin-1-yl)methanone
• Synonyms: (2,3-diphenyl-indol-1-yl)(piperidin-1-yl)methanone
• CAS NO: 1008303-73-8
• Molecular Weight: 380.489
• Mol File: 1008303-73-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2,3-diphenyl-indol-1-yl)(piperidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-diphenyl-indol-1-yl)(piperidin-1-yl)methanone(1008303-73-8)
• EPA Substance Registry System: (2,3-diphenyl-indol-1-yl)(piperidin-1-yl)methanone(1008303-73-8)

Safety Data

• Hazardous Substances Data: 1008303-73-8(Hazardous Substances Data)

Upstream product

• 2645-36-5 1-(N-phenylcarbamoyl)piperidine 
• 501-65-5 diphenyl acetylene 
• 110-89-4 piperidine 
• 88-67-5 2-Iodobenzoic acid 
• 1885-14-9 phenyl chloroformate 

Relevant articles and documents

Control over Organometallic Intermediate Enables Cp?Co(III) Catalyzed Switchable Cyclization to Quinolines and Indoles

Achieving controllable C-H functionalization to elaborate valuable compounds from simple chemicals is attractive and highly desirable, especially if nonprecious transition metal catalysts can be used. However, controlling selectivity in these transformations remains a continuous challenge to synthetic chemists. Herein, we show for the first time that control over the reactive organometallic intermediate enables the switchable synthesis of quinoline and indole from amides and alkynes through C-H activation using Cp?Co(III). The keys to this strategy are (1) introducing a Lewis acid to greatly accelerate the dehydrative cyclization, which can outcompete dehydrogenative cyclization, and (2) tuning the directing group to facilitate the dehydrogenative cyclization and inhibit dehydrative cyclization.