1008531-03-0Relevant articles and documents
Microwave assisted ring-opening of epoxides with N-biaryl sulfonamides in the synthesis of matrix metalloproteinase-9 inhibitors
Yang, Shyh-Ming,Murray, William V.
, p. 835 - 839 (2008/04/13)
A microwave accelerated epoxide ring-opening process with N-biaryl sulfonamides is described. Under this mild, highly efficient condition, an α-hydroxy-β-N-biaryl sulfonamide skeleton is rapidly assembled leading ultimately to a novel series of matrix met
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 2. Optimization of α-amino substituents
Yang, Shyh-Ming,Scannevin, Robert H.,Wang, Bingbing,Burke, Sharon L.,Huang, Zhihong,Karnachi, Prabha,Wilson, Lawrence J.,Rhodes, Kenneth J.,Lagu, Bharat,Murray, William V.
, p. 1140 - 1145 (2008/09/19)
The introduction and the optimization of an α-amino substituent based on a series of α-hydroxy-β-N-biaryl ether sulfonamide hydroxamates is described. The modification leads to a new series of MMP-2/MMP-9 inhibitors with enhanced inhibitory activities and