100874-12-2

Basic information

• Product Name: Benzoic acid, 2-[(4-bromobenzoyl)amino]-
• CAS NO: 100874-12-2
• Molecular Formula: C14H10BrNO3
• Molecular Weight: 320.142
• Mol File: 100874-12-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(4-bromobenzoyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(4-bromobenzoyl)amino]-(100874-12-2)
• EPA Substance Registry System: Benzoic acid, 2-[(4-bromobenzoyl)amino]-(100874-12-2)

Safety Data

• Hazardous Substances Data: 100874-12-2(Hazardous Substances Data)

Upstream product

• 6127-49-7 2-(4-bromophenyl)indole 
• 144294-89-3 4'-bromo-1H-2-phenyl-3-hydroxy-4-oxoquinoline 
• 586-75-4 4-chlorobenzoyl chloride 
• 118-92-3 anthranilic acid 
• 18600-53-8 2-(4-bromophenyl)-4H-benzo[d][1,3]oxazine-4-one 
• 2159-40-2 2-(4-bromobenzoyl)benzoic acid 

Downstream Products

• 18600-53-8 2-(4-bromophenyl)-4H-benzo[d][1,3]oxazine-4-one 

Relevant articles and documents

Substituent effects on hydrogen bonding of aromatic amide-carboxylate

N-(p-benzoyl)-anthranilic acid (BAA) derivatives have been synthesized with different substituents (X: Br, Cl, OCH3, CH3), and their crystal structures have been analyzed in order to understand the variations in their molecular geome

A straightforward TBHP-mediated synthesis of 2-amidobenzoic acids from 2-arylindoles and their antimicrobial activity

A simple and highly efficient strategy has been developed for the synthesis of 2-amidobenzoic acids through the tert-butyl hydroperoxide (TBHP)-mediated oxygenation and sequential ring opening of 2-arylindoles in a one-pot fashion under metal-free aerobic conditions. The developed synthetic protocol is operationally simple, tolerates a wide range of functional groups, and is amenable to the gram-scale. Radical trapping experiments revealed that the reaction involves a radical pathway. The synthesized compounds (2a-s) were tested for in vitro antimicrobial activity. Among all screened compounds, 2d showed the maximum antibacterial activity against P. aerugunosa (ZOI = 17 mm, MIC = 32 μg mL-1) and compounds 2d and 2p showed the maximum (32 μg mL-1) antifungal activity against A. flavus and C. albicans.

Bio-inspired flavonol and quinolone dioxygenation by a non-heme iron catalyst modeling the action of flavonol and 3-hydroxy-4(1H)-quinolone 2,4-dioxygenases

The mononuclear complex, FeIII(O-bs)(salen) (salenH2 = 1,6-bis(2-hydroxyphenyl)-2,5-diaza-hexa-1,5-diene; O-bsH = O-benzoylsalicylic acid) was synthesized as synthetic enzyme-depside complex, and characterized by spectroscopic methods and X-ray crystal analysis. The dioxygenation of flavonol (flaH) and 3-hydroxy-4-quinolone (quinH2) derivatives in the presence of catalytic amounts of FeIII(O-bs)(salen) results in the oxidative cleavage of the heterocyclic ring to give the corresponding O-benzoylsalicylic and anthranilic acid derivatives with concomitant release of carbon monoxide. These reactions can be regarded as biomimetic functional models with relevance to the iron-containing flavonol and the cofactor-independent 3-hydroxy-4(1H)-quinolone 2,4-dioxygenases.