100929-35-9

Basic information

• Product Name: Acetic acid (R)-2-acetylamino-2-cyclohexyl-ethyl ester
• CAS NO: 100929-35-9
• Molecular Weight: 227.304
• Mol File: 100929-35-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid (R)-2-acetylamino-2-cyclohexyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (R)-2-acetylamino-2-cyclohexyl-ethyl ester(100929-35-9)
• EPA Substance Registry System: Acetic acid (R)-2-acetylamino-2-cyclohexyl-ethyl ester(100929-35-9)

Safety Data

• Hazardous Substances Data: 100929-35-9(Hazardous Substances Data)

Upstream product

• 14328-52-0 (R)-2-amino-2-cyclohexyl acetic acid 
• 875-74-1 (R)-phenylglycine 
• 85711-13-3 (R)-(-)-2-amino-2-cyclohexylethan-1-ol 
• 75-36-5 acetyl chloride 

Downstream Products

• 100929-31-5 N-((R)-1-Cyclohexyl-2-hydroxy-ethyl)-3-hydroxy-3-phenyl-propionamide 
• 100929-28-0 (R)-2-(Acetylamino)-2-cyclohexylethanol 

Relevant articles and documents

Stereoselective Aldol Reaction with Chiral Secondary Acetamides

The deprotonated acetamides 4a - c and 5a - c are added to prochiral carbonyl compounds.The influence of the solvent, of the reaction temperature, and of the enolate gegenion on the ratio of the isomeric products 8/9, 18/19, and 26/27, respectively, are studied.The highest degree of diastereoselectivity are observed, when the titanium enolate of the acetamide 4a or the threefold deprotonated N-acetyl-α-phenylglycinol (5a) is used.The diastereomers 18a - d, formed in excess in the addition of 5a to aldehydes, are isolated in pure from by a single recrystallization, and afford the enantiomerically pure β-hydroxy carboxylic acids 3a - d.Thereby, the chiral auxiliary, α-phenylglycinol (14), is recovered.