100930-02-7 Usage
Description
ARG-TYR-LEU-PRO-THR ACETATE SALT, also known as Proctolin, is a bioactive neuropeptide that was the first to be isolated and structurally characterized from insect tissues. It is composed of five amino acids: arginine, tyrosine, leucine, proline, and threonine, and is found in insects and crustaceans. Proctolin exhibits a range of activities, such as myotropic action, regulation of juvenile hormone synthesis, and behavioral influences.
Uses
Used in Neuropeptide Research:
ARG-TYR-LEU-PRO-THR ACETATE SALT is used as a research tool for studying the functions and mechanisms of neuropeptides in insects and crustaceans. It helps researchers understand the roles of neuropeptides in various biological processes, including muscle contraction, hormone regulation, and behavior.
Used in Pharmaceutical Development:
Proctolin is used as a potential therapeutic agent for developing drugs targeting neuropeptide-related disorders. Its diverse activities and effects on various physiological processes make it a promising candidate for the treatment of conditions such as muscle disorders, hormonal imbalances, and neurological diseases.
Used in Insect and Crustacean Biology:
ARG-TYR-LEU-PRO-THR ACETATE SALT is used as a biological marker for studying the biology and ecology of insects and crustaceans. It helps researchers identify and classify different species based on their neuropeptide composition and understand the role of neuropeptides in their survival, reproduction, and adaptation to environmental changes.
Discovery
Proctolin was first identified in 1975 from the whole body of the American cockroach Periplaneta americana, based upon its ability to stimulate hindgut contractions.
Synthesis
The gene encoding a proctolin precursor protein was first identified in the fruit fly Drosophila melanogaster.
The predicted protein encoded by Proct has a single copy
of the Arg-Tyr-Leu-Pro-Thr sequence that directly follows the predicted signal peptidase cleavage point
flanked by a potential peptide cleaving site,
and similar precursor structures are conserved in other
insects and in noninsect arthropods.?The proctolin gene has been found in a various arthropods except
for Hymenoptera, Lepidoptera, and the yellow fever
mosquito Aedes aegypt.Proctolin is thought to be synthesized and packaged into dense core vesicles in the cell
body of neurons and then transported down the axon
to the synaptic terminals.In arthropods, proctolin acts
as a cotransmitter as well as a neurohormone.
Biological functions
Proctolin displays potent myotropic activity in the visceral, cardiac, and skeletal muscle from a range of insect species. In addition, proctolin may act as a releasing factor for adipokinetic hormone (AKH) and juvenile hormone (JH) in the locust.However, it does not regulate JH release in the cockroach. Moreover, proctolin plays a modulatory role in a neuronal circuit controlling sexual behavior in the bow-winged grasshopper Chorthippus biguttulus.
Enzyme inhibitor
This insect neuromodulator/neurotransmitter/ neurohormone (FW = 648.76 g/mol; CAS : 100930-02-7; Sequence: L-Arg-L-Tyr-L-Leu-L-Pro-L-Thr) exerts its proctolinergic action by changing the way impulses are transmitted across a synapse, often assisting a more common neurotransmitter, such as glutamate. Mode of Action: Proctolin potently stimulates visceral and skeletal muscles contraction of a number of in insects. The Drosophila melanogaster proctolin receptor (CG6986) is an orphan G-protein coupled receptor and is strongly expressed in the head, the larval hindgut, the aorta and on neuronal endings in adult hearts. Unlike classical neurotransmitters, proctolin does not change the postsynaptic conductance. It also modulates reproductive tissue, stimulating contractions of the oviducts in the American cockroach Periplaneta americana, as well as Leucophaea maderae, L. migratoria, and spermathecae in L. migratoria and Rhodnius prolixus. Proctolin also speeds up heart rate in some insects. Target(s); dipeptidyl-peptidase III, or aminoenkephalinase.
Check Digit Verification of cas no
The CAS Registry Mumber 100930-02-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,3 and 0 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100930-02:
(8*1)+(7*0)+(6*0)+(5*9)+(4*3)+(3*0)+(2*0)+(1*2)=67
67 % 10 = 7
So 100930-02-7 is a valid CAS Registry Number.