1009344-67-5

Basic information

• Product Name: N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide
• Synonyms: N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide
• CAS NO: 1009344-67-5
• Molecular Weight: 298.223
• Mol File: 1009344-67-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 374.6±30.0 °C(Predicted)
• Density: 1.256±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide(1009344-67-5)
• EPA Substance Registry System: N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide(1009344-67-5)

Safety Data

• Hazardous Substances Data: 1009344-67-5(Hazardous Substances Data)

Upstream product

• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 24596-19-8 4-bromo-2,6-dimethylphenylamine 

Downstream Products

• 1009344-20-0 N-(4-(3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide 
• 1009344-53-9 N-[2,6-Dimethyl-4-(7-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-3,3-dimethyl-butanamide 
• 1009344-33-5 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide 
• 1009344-28-8 N-[2,6-Dimethyl-4-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-3,3-dimethyl-butanamide 
• 1009344-37-9 N-[4-(7-Fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethyl-phenyl]-3,3-dimethyl-butanamide 
• 1009344-32-4 N-[4-(6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethyl-phenyl]-3,3-dimethyl-butanamide 
• 1108192-89-7 N-[2,6-dimethyl-4-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-phenyl]-3,3-dimethyl-butanamide 
• 1108192-85-3 N-[2,6-dimethyl-4-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-phenyl]-3,3-dimethyl-butyramide 

Relevant articles and documents

Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy

KCNQ (Kv7) has emerged as a validated target for the development of novel anti-epileptic drugs. In this paper, a series of novel N-phenylbutanamide derivatives were designed, synthesized and evaluated as KCNQ openers for the treatment of epilepsy. These compounds were evaluated for their KCNQ opening activity in vitro and in vivo. Several compounds were found to be potent KCNQ openers. Compound 1 with favorable in vitro activity was submitted to evaluation in vivo. Results showed that compound 1 owned significant anti-convulsant activity with no adverse effects. It was also found to posses favorable pharmacokinetic profiles in rat. This research may provide novel potent compounds for the discovery of KCNQ openers in treating epilepsy.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

STABLE FORMS OF N-(2,6-DIMETHYL-4-MORPHOLIN-4-YL-PHENYL)-3,3-DIMETHYL-BUTYRAMIDE

Polymorphic forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl- butyramideare provided together with a process for the manufacture of said compound.