1009369-03-2Relevant articles and documents
Discovery of phthalimides as immunomodulatory and antitumor drug prototypes
Pessoa, Claudia,Ferreira, Paulo Michel P.,Lotufo, Leticia Veras C.,DeMoraes, Manoel O.,Cavalcanti, Suellen M. T.,Coelho, Lucas Cunha D.,Hernandes, Marcelo Z.,Leite, Ana Cristina L.,DeSimone, Carlos A.,Costa, Vlaudia M. A.,Souza, Valdenia M. O.
, p. 523 - 528 (2010)
Optimized anticancer agents: A set of functionalized phthalimides was synthesized and evaluated for antitumor activities and as modulators of the secretion of cytokines and nitric oxide. Their potency was compared with that of thalidomide, and as a result, a new potent anticancer and immunomodulatory agent, compound 2b, was identified.