1009378-92-0

Basic information

• Product Name: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid
• Synonyms: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid
• CAS NO: 1009378-92-0
• Molecular Weight: 314.338
• Mol File: 1009378-92-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid(1009378-92-0)
• EPA Substance Registry System: 4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid(1009378-92-0)

Safety Data

• Hazardous Substances Data: 1009378-92-0(Hazardous Substances Data)

Upstream product

• 34040-62-5 o-(chloromethyl)benzoic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 55453-89-9 4-(2-carboxybenzyloxy) phenyl acetic acid 
• 55453-87-7 isoxepac 
• 113806-05-6 olopatadine 
• 113806-06-7 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid 
• 140462-76-6 olopatadine hydrochloride 

Relevant articles and documents

A process for the preparation of olopatadine hydrochloride

The invention relates to a method for preparing a compound, namely, olopatadine hydrochloride. The method specifically comprises the following steps: by taking 2-chloromethyl methyl benzoate and methyl 4-hydroxyphenylacetate as initial raw materials, performing etherification, hydrolysis and cyclization, further performing wittig reaction, and salifying, thereby synthesizing olopatadine hydrochloride. The process is gentle in process reaction condition, acetic anhydride is adopted to replace polyphosphoric acid, a hydrochloric acid organic solvent is adopted to effectively split Z/E type olopatadine so as to obtain olopatadine hydrochloride, conversion of Z/E configuration is effectively achieved after an E configuration byproduct is treated by using concentrated hydrochloric acid, the yield of olopatadine hydrochloride is increased, the product purity is good, and the feasibility of industrialization production is greatly improved.

TERTIARY ALKYL ESTER OF OXODIBENZOXEPIN ACETIC ACID

A tertiary alkyl ester represented by Formula (2): wherein R1 and R2 each independently represent a C1-4 alkyl group, and a method for producing the same.