100944-15-8 Usage
Description
(1R,4R)-5-(PHENYLMETHYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE, also known as RTI-55, is a chemical compound that functions as a potent and selective dopamine reuptake inhibitor. It has garnered attention for its potential therapeutic applications in various neurological and psychiatric conditions due to its ability to modulate dopamine levels in the brain.
Uses
Used in Substance Abuse Treatment:
(1R,4R)-5-(PHENYLMETHYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE is used as a therapeutic agent for the treatment of cocaine addiction and other substance abuse disorders. It operates by blocking the effects of dopamine reuptake, which results in decreased feelings of reward and reinforcement associated with drug use, thereby potentially aiding in the reduction of drug-seeking behavior.
Used in Neurodegenerative Disorder Treatment:
In the field of neurodegenerative disorders, (1R,4R)-5-(PHENYLMETHYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE is used as a potential treatment for Parkinson's disease. Its dopamine-modulating properties may help alleviate symptoms associated with this disorder by increasing the availability of dopamine in the brain.
However, it is important to note that the use of (1R,4R)-5-(PHENYLMETHYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE DIHYDROBROMIDE has been limited due to its high potential for abuse and addiction, which necessitates careful consideration and management in clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 100944-15-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,4 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 100944-15:
(8*1)+(7*0)+(6*0)+(5*9)+(4*4)+(3*4)+(2*1)+(1*5)=88
88 % 10 = 8
So 100944-15-8 is a valid CAS Registry Number.
100944-15-8Relevant articles and documents
Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis
Laskar, Sujay,Sánchez-Sánchez, Luis,López-Ortiz, Manuel,López-Mu?oz, Hugo,Escobar-Sánchez, María L.,Sánchez, Arturo T.,Regla, Ignacio
, p. 1129 - 1135 (2017/09/18)
Identification of a new class of antitumor agent capable to induce apoptosis without triggering necrotic cell death event is challenging. The present communication describes the multicomponent synthesis of seven new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro antiproliferative activity on cervical cancer cell line (CaSki), breast cancer cell line (MDA-MB231), lung cancer cell line (SK-Lu-1) and human lymphocytes. Among the synthesized dithiocarbamates, compound 9e displayed significant antiproliferative activity without inducing any necrotic cell death (both on tumour cells and lymphocytes) and induced apoptosis in tumor cells by the caspase dependent apoptotic pathway. The compound 9e also exhibited greater tumor selectivity than human lymphocytes. In silico ADME predictions revealed that compound 9e has the potential to be developed as a drug candidate. Rapid chemical modifications of this lead are thus highly necessary for further investigation as a drug like safer antitumor candidate and also to achieve compounds with better activity profile.
Synthesis of (1R,4R)- and (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes and their N-substituted derivatives
Jordis,Sauter,Siddiqi,Kuenburg,Bhattacharya
, p. 925 - 930 (2007/10/02)
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