100944-90-9

Basic information

• Product Name: 1-(chloromethoxymethyl)-3-methylbenzene
• Synonyms: 1-(chloromethoxymethyl)-3-methylbenzene
• CAS NO: 100944-90-9
• Molecular Weight: 170.639
• Mol File: 100944-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(chloromethoxymethyl)-3-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(chloromethoxymethyl)-3-methylbenzene(100944-90-9)
• EPA Substance Registry System: 1-(chloromethoxymethyl)-3-methylbenzene(100944-90-9)

Safety Data

• Hazardous Substances Data: 100944-90-9(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 587-03-1 3-methylbenzyl alcohol 

Downstream Products

• 1875-89-4 2-(3-methylphenyl)ethanol 

Relevant articles and documents

[1,2]-Wittig rearrangement from chloromethyl ethers

The reaction of different chloromethyl ethers 1 with an excess of lithium powder and a catalytic amount of 4,4′-di-tert-butylbiphenyl (2.5 mol %) in THF at 0 °C leads to the corresponding α-lithiomethyl ether intermediates, through a chlorine-lithium exchange, which spontaneously undergo a clean [1,2]-Wittig rearrangement affording the expected homobenzylic alcohols 2. This is the first version of this rearrangement starting from easily available chloromethyl ethers.