100949-40-4Relevant articles and documents
Synthesis of α,β-unsaturated nitriles from the iodine catalyzed reaction of chloroacetonitrile with aldehydes promoted by tri-n-butylarsine and magnesium
Shen, Yanchang,Yang, Baozhen
, p. 4693 - 4698 (1996)
α,β-Unsaturated nitriles were synthesized from the iodine catalyzed reaction of chloro- acetonitrile with aldehydes promoted by tri-n-butylarsine and magnesium.
(E)-3-heteroaromatic propyl-2-enoic acid derivative as well as preparation and application thereof
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Paragraph 0057-0058; 0060, (2020/09/10)
The invention relates to a (E)-3-heteroaromatic propyl-2-enoic acid derivative, and also relates to a preparation method and pharmaceutical application thereof. The compound is a novel Nrf2 activatorand has the effects of resisting oxidative stress, resisting neuritis and enhancing mitochondrial functions and biogenesis by effectively activating an Nrf2 signal path, so that nerve cells are protected, and the compound can be used for treating neurodegenerative diseases and cerebral apoplexy. In addition, the novel Nrf2 activator can also be used to treat autoimmune diseases, diabetes and nephropathy, and other chronic diseases.
A Catalytic Peterson-like Synthesis of Alkenyl Nitriles
Lanari, Daniela,Alonzi, Matteo,Ferlin, Francesco,Santoro, Stefano,Vaccaro, Luigi
supporting information, p. 2680 - 2683 (2016/06/15)
A heterogeneous fluoride catalyst was found to enable the straightforward formation of alkenyl nitriles from the reaction of aldehydes and simple or substituted acetonitriles, in the presence of commercially available silazanes and in solvent-free conditions. The protocol afforded the products in good to excellent yields with selectivity values dependent on the nature of the substrates. It represents an alternative to classic approaches using stoichiometric strong bases, and the catalyst can be easily recovered and reused for consecutive cycles.