100986-37-6

Basic information

• Product Name: Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester
• Synonyms: Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester
• CAS NO: 100986-37-6
• Molecular Weight: 259.348
• Mol File: 100986-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester(100986-37-6)
• EPA Substance Registry System: Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester(100986-37-6)

Safety Data

• Hazardous Substances Data: 100986-37-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 18700-22-6 8-methyl-8-azabicyclo<3.2.1>octane 
• 77923-96-7 6β-phenyl-8-methyl-6α-hydroxy-8-azabicyclo<3.2.1>octane 
• 542-05-2 acetonedicarboxylic acid 
• 18700-21-5 6β-hydroxy-8-methyl-8-azabicyclo<3.2.1>octane 
• 100986-40-1 6β-hydroxy-8-methyl-8-azabicyclo<3.2.1>octan-3-one hydrazone 
• 5932-53-6 6β-hydroxy-8-methyl-8-azabicyclo<3.2.1>octan-3-one 

Relevant articles and documents

Novel 6-substituted 8-azabicyclo [3.2.1.] octanes as potential opiate agonists and antagonists

Reaction of 8-methyl-8-azabicyclo[3.2.1]octan-6-one (tropan-6-one) with aryl magnesium halides selectively yields 6β-aryl-6α-hydroxy-8-methyl-8-azabicyclo[3.2.1]octanes (6β-aryl-6α-hydroxytropanes). 1H nmr studies supporting the assignment are presented, together with 13C data of these alcohols and various derivatives prepared as potential agonists and antagonists of opiate receptors. The results from 1H nmr studies of 6-hydroxytropan-3-one, the synthesis of which was reported in 1952, support the assigned 6β-hydroxy stereochemistry.