1010073-10-5Relevant articles and documents
Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis
Yao, Wenqing,Zhuo, Jincong,Burns, David M.,Li, Yun-Long,Qian, Ding-Quan,Zhang, Colin,He, Chunhong,Xu, Meizhong,Shi, Eric,Li, Yanlong,Marando, Cindy A.,Covington, Maryanne B.,Yang, Gengjie,Liu, Xiangdong,Pan, Max,Fridman, Jordan S.,Scherle, Peggy,Wasserman, Zelda R.,Hollis, Gregory,Vaddi, Kris,Yeleswaram, Swamy,Newton, Robert,Friedman, Steve,Metcalf, Brian
, p. 159 - 163 (2008/09/19)
In an effort to obtain a MMP selective and potent inhibitor of HER-2 sheddase (ADAM-10), the P1′ group of a novel class of (6S,7S)-7-[(hydroxyamino)carbonyl]-6-carboxamide-5-azaspiro[2.5]octane-5-carboxylates was attenuated and the structure-activity rela
