1010085-13-8 Usage
Description
MK-5108 (VX-689) is a pharmaceutical compound that functions as a highly selective Aurora-A kinase inhibitor. It is designed to target and inhibit the Aurora-A kinase, which plays a crucial role in cell division and is often overexpressed in various types of cancer. By inhibiting this enzyme, MK-5108 (VX-689) can potentially disrupt the abnormal cell division and growth associated with cancer, making it a promising candidate for cancer treatment.
Uses
Used in Oncology:
MK-5108 (VX-689) is used as an antitumor agent for its ability to inhibit Aurora-A kinase, which is often overexpressed in various types of cancer. This selective inhibition can help disrupt the abnormal cell division and growth associated with cancer, making it a potential therapeutic option for cancer patients.
MK-5108 (VX-689) is also used in combination with Docetaxel (D494420), a chemotherapy drug, to enhance the overall antitumor activity. The combination therapy aims to improve the treatment outcomes by leveraging the synergistic effects of both drugs, potentially leading to better responses and increased survival rates in cancer patients.
Biological Activity
mk-5108, also known as vx-689, is a novel, potent and selective inhibitor of aurora a kinase (aak) that competitively binds to the atp binding site of aak and hence potently inhibits the activity of aak with 50% inhibition concentration ic50 value of 0.064 nm. mk-5108 also inhibits other members of aurora kinase family, including aurora b kinase (ic50 = 14 nm) and aurora c kinase (ic50 = 12 nm), with a lesser potency. mk-5108 has been extensively studies and found to exhibit antitumor activity in a wide range of cancer types, including breast, cervix, colorectal, ovary and pancreas neoplasms.myke r. green, bs, pharm.d., bcop, joseph e. woolery, bs, pharm.d, and daruka mahadevan, md, phd. update on aurora kinase targeted therapeutics in oncology. recent pat anticancer drug discov. 2008 november ; 3(3): 162–177.
Check Digit Verification of cas no
The CAS Registry Mumber 1010085-13-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,0,0,8 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1010085-13:
(9*1)+(8*0)+(7*1)+(6*0)+(5*0)+(4*8)+(3*5)+(2*1)+(1*3)=68
68 % 10 = 8
So 1010085-13-8 is a valid CAS Registry Number.
InChI:InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-
