1010101-15-1

Basic information

• Product Name: 1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)pyridin-2(1H)-one
• Synonyms: 1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)pyridin-2(1H)-one
• CAS NO: 1010101-15-1
• Molecular Weight: 417.816
• Mol File: 1010101-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)pyridin-2(1H)-one(1010101-15-1)
• EPA Substance Registry System: 1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)pyridin-2(1H)-one(1010101-15-1)

Safety Data

• Hazardous Substances Data: 1010101-15-1(Hazardous Substances Data)

Upstream product

• 87486-35-9 1-benzyl-3,5-dichloro-1H-pyrazin-2-one 
• 159087-46-4 4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1010101-14-0 1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one 
• 1417647-19-8 1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one 
• 1417647-21-2 1-benzyl-5-bromo-3-chloro-4-(trimethylsilyl)pyridin-2(1H)-one 

Relevant articles and documents

Scalable synthesis of functionalised 2-pyridones via [4+2] cycloaddition reactions of 2-pyrazinones and alkynylboronates

The multigram synthesis of N-protected 2-pyridone boronic acid derivatives via a [4+2] cycloaddition of alkynylboronates with 2-pyrazinones is presented. The reactions are highly chemoselective, and generally highly regioselective although trimethylsilyl-substituted alkynylboronates have proven to be an exception. Nonetheless, in this latter case, separation of regioisomers was successfully accomplished via high performance counter-current chromatography allowing isolation of analytically pure 2-pyridones. Further derivatisations of trimethylsilyl-substituted 2-pyridone boronates were performed providing access to a selection of functionalised scaffolds.