101064-48-6

Basic information

• Product Name: MICROCYSTIN YR
• Synonyms: MICROCYSTIN YR;microcystin yr from microcystis aeruginosa;MICROCYSTIN-YR SOLUTION;Cyanoginosin la, 3-L-tyrosine-5-L-arginine;Cyanoginosin la, 3-L-tyrosyl-5-L-arginine;Cyanoginosin la, 3-tyrosyl-5-arginine-;Cyanoginosin yr;Cyanoginosin-yr
• CAS NO: 101064-48-6
• Molecular Formula: C52H72N10O13
• Molecular Weight: 1045.19
• EINECS: 200-659-6
• Product Categories: Cyanobacterial ToxinsTyrosine Phosphatase Biology;Protein Phosphatase 2 (PP2);Tyrosine Phosphatase Inhibitors;Application Index;Cell Signaling Enzymes;Natural Products
• Mol File: 101064-48-6.mol
• Article Data: 0

Chemical Properties

• Flash Point: 11 °C
• Appearance: /white powder
• Density: 1.33 g/cm³
• Refractive Index: 1.615
• Storage Temp.: −20°C
• Solubility: methanol: 2 mg/mL (further dilute to 10% (v/v) methanol)
• PKA: 3.02±0.70(Predicted)
• CAS DataBase Reference: MICROCYSTIN YR(CAS DataBase Reference)
• NIST Chemistry Reference: MICROCYSTIN YR(101064-48-6)
• EPA Substance Registry System: MICROCYSTIN YR(101064-48-6)

Safety Data

• Hazard Codes: T+,T,F
• Statements: 26/27/28-36/37/38-43-39/23/24/25-23/24/25-11
• Safety Statements: 26-36/37/39-45-36/37-16-7
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: 000000030272
• Hazardous Substances Data: 101064-48-6(Hazardous Substances Data)

Usage

Uses

Microcystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples.

General Description

Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO2 and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs.

Biochem/physiol Actions

Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h.

InChI:InChI=1/C52H72N10O13/c1-28(25-29(2)41(75-8)27-34-13-10-9-11-14-34)16-21-37-30(3)44(65)59-39(50(71)72)22-23-42(64)62(7)33(6)47(68)56-32(5)46(67)60-40(26-35-17-19-36(63)20-18-35)49(70)61-43(51(73)74)31(4)45(66)58-38(48(69)57-37)15-12-24-55-52(53)54/h9-11,13-14,16-21,25,29-32,37-41,43,63H,6,12,15,22-24,26-27H2,1-5,7-8H3,(H,56,68)(H,57,69)(H,58,66)(H,59,65)(H,60,67)(H,61,70)(H,71,72)(H,73,74)(H4,53,54,55)/b21-16+,28-25+/t29-,30-,31-,32+,37-,38-,39+,40+,41-,43+/m0/s1