101080-03-9

Basic information

• Product Name: 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene
• Synonyms: 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene;4-Chloro-5-methyl-2-nitroanisole;5-Chloro-2-methoxy-4-methyl-1-nitrobenzene
• CAS NO: 101080-03-9
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.60702
• Mol File: 101080-03-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene(101080-03-9)
• EPA Substance Registry System: 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene(101080-03-9)

Safety Data

• Hazardous Substances Data: 101080-03-9(Hazardous Substances Data)

Usage

General Description

1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene is a chemical compound with the molecular formula C8H8ClNO3. It is an aromatic compound that belongs to the nitrobenzene class. 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene is a yellowish solid that is used in organic synthesis and as an intermediate for the production of pharmaceuticals, dyes, and other specialty chemicals. It is also used as a building block in the synthesis of various organic compounds due to its reactivity and versatility. Additionally, 1-Chloro-4-Methoxy-2-Methyl-5-nitro-benzene may have potential applications in the field of medicinal chemistry and pharmacology due to its structural features. However, it is important to handle this compound with caution as it may pose health hazards and environmental risks if not managed properly.

Upstream product

• 7147-89-9 4-chloro-5-methyl-2-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 67-68-5 dimethyl sulfoxide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 6815-42-5 4-chloro-3-methyl-2-nitrophenol 
• 186581-53-3 diazomethane 

Downstream Products

• 1356016-29-9 2-chloro-5-methoxy-4-nitro-N-phenyl-benzamide 
• 82128-70-9 5-chloro-2-methoxy-4-methylbenzaldehyde 
• 1001347-19-8 4-amino-2-chloro-5-methoxybenzoic acid 
• 1380308-20-2 1-bromomethyl-2-chloro-5-methoxy-4-nitro-benzene 
• 1356016-30-2 4-amino-2-chloro-5-methoxy-N-phenylbenzamide 
• 1360616-09-6 (2-chloro-5-methoxy-4-nitro-phenyl)-methanol 
• 1349744-88-2 methyl 2-chloro-5-methoxy-4-nitrobenzoate 
• 886981-69-7 1-(5-chloro-4-formyl-2-methoxy-phenyl)-3-(5-cyano-pyrazin-2-yl)-urea 
• 886981-66-4 N-(4-bromomethyl-5-chloro-2-methoxy-phenyl)-2,2,2-trifluoro-acetamide 
• 886981-67-5 N-(5-chloro-4-formyl-2-methoxy-phenyl)-2,2,2-trifluoro-acetamide 
• 886981-68-6 4-amino-2-chloro-5-methoxy-benzaldehyde 
• 569688-67-1 5-chloro-2-methoxy-4-methylphenylamine 
• 101581-13-9 2-chloro-5-methoxy-4-nitrobenzoic acid 

Relevant articles and documents

ISOINDOLINONE COMPOUNDS

Disclosed herein is a compound or pharmaceutically acceptable salts or stereoisomers thereof of of formula I wherein X1 is linear or branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C1-6 alkyl C6-10 aryl, C1-6 alkyl 5-10 membered heteroaryl, wherein X1 is unsubstituted or substituted with one or more of halogen, linear or branched C1-6 alkyl, linear or branched C1-6 heteroalkyl, CF3, CHF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C1-6 alkylamino, -CN, -N(H)C(O)-C1- 6alkyl, -OC(O)-C1-6alkyl, -OC(O)-C1-4alkylamino, -C(O)O-C1-6alkyl, -COOH, - CHO, -C1-6alkylC(O)OH, -C1-6alkylC(O)O-C1-6alkyl, NH2, C1-6 alkoxy or C1-6 alkylhydroxy; X2 is hydrogen, C6-10 aryl, 5-10 membered heteroaryl, -O-(5-10 membered heteroaryl), 4-8 membered heterocycloalkyl, C1-4 alkyl 4-8 membered heterocycloalkyl, -O-(4-8 membered heterocycloalkyl), -O-C1-4 alkyl-(4-8 membered heterocycloalkyl), -OC(O)-C1-4alkyl-4-8 membered heterocycloalkyl or C6 aryloxy, wherein X2 is unsubstituted or substituted with one or more of linear or branched C1-6 alkyl, NH2, NMe2 or 5-6 membered heterocycloalkyl; n is 0, 1 or 2.

NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.