1010800-80-2

Basic information

• Product Name: 4-(t-Butyldimethylsilyloxy)-3-methoxypropiophenone
• Synonyms: 4-(t-Butyldimethylsilyloxy)-3-methoxypropiophenone
• CAS NO: 1010800-80-2
• Molecular Weight: 294.466
• Mol File: 1010800-80-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(t-Butyldimethylsilyloxy)-3-methoxypropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(t-Butyldimethylsilyloxy)-3-methoxypropiophenone(1010800-80-2)
• EPA Substance Registry System: 4-(t-Butyldimethylsilyloxy)-3-methoxypropiophenone(1010800-80-2)

Safety Data

• Hazardous Substances Data: 1010800-80-2(Hazardous Substances Data)

Upstream product

• 69404-94-0 O-tert-butyldimethylsilylvanillin 
• 925-90-6 ethylmagnesium bromide 
• 210555-50-3 C₁₆H₂₈O₃Si 
• 121-33-5 vanillin 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1010800-81-3 methyl 4-[4-(t-butyldimethylsilyloxy)-3-methoxyphenyl]-3-methyl-4-oxobutanoate 
• 10035-17-3 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one 
• 171485-39-5 erythro-Δ^8’-4,7-dihydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan 

Relevant articles and documents

Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (8′-7-ethoxy-4-hydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan (1) with an EC50 of 0.332 μM, which was isolated from a well-known spice, nutmeg (Myristica fragrans Houtt.). Structure activity relationships are also disclosed, showing that the 7-d-menthoxy derivative is the most potent agonist (EC50 = 11 nM). The combination of 1 and l-(-)-menthol has an additive effect, suggesting that neolignan compounds interact with TRPM8 at different sites from those of l-(-)-menthol.

Cooling Agent and TRPM8 Activator

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingre

PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT

It is to provide a novel pyrazolone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1,R2: C1-6 alkyl; R3,R4: H, X, C1-6 alkoxy; Z:O, S; A:AA, BB, wherein AA represents wherein BB represents wherein R5: H, C1-6 alkyl ; R6,R7: C1-6 alkyl.