1010857-57-4

Basic information

• Product Name: 5,7-dinitro-3-phenyl-2-chloroquinoxaline
• Synonyms: 5,7-dinitro-3-phenyl-2-chloroquinoxaline
• CAS NO: 1010857-57-4
• Molecular Weight: 330.687
• Mol File: 1010857-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,7-dinitro-3-phenyl-2-chloroquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dinitro-3-phenyl-2-chloroquinoxaline(1010857-57-4)
• EPA Substance Registry System: 5,7-dinitro-3-phenyl-2-chloroquinoxaline(1010857-57-4)

Safety Data

• Hazardous Substances Data: 1010857-57-4(Hazardous Substances Data)

Upstream product

• 1010857-55-2 5,7-dinitro-3-phenylquinoxalin-2(1H)one 

Downstream Products

• 1010857-64-3 N-[4-(5,7-dinitro-3-phenylquinoxalin-2-ylamino)benzoyl]-L-glutamic acid diethyl ester 
• 1010857-62-1 C₂₀H₁₁Cl₂N₅O₄ 
• 1010857-61-0 C₂₃H₁₉N₅O₇ 
• 1010857-63-2 2-[(4-fluorophenyl)amino]-3-phenyl-5,7-dinitroquinoxaline 
• 1010857-60-9 C₂₂H₁₇N₅O₆ 
• 1148020-89-6 5,7-dinitro-3-phenyl-2-(3,5-dimethoxyphenoxy)quinoxaline 
• 1148020-92-1 5,7-dinitro-3-phenyl-2-(4-fluorophenoxy)quinoxaline 
• 1017622-31-9 5,7-dinitro-3-phenyl-2-(3,4-dimethoxyphenoxy)quinoxaline 
• 1148020-95-4 5,7-dinitro-3-phenyl-2-(4-fluorophenylthio)quinoxaline 
• 1148020-93-2 5,7-dinitro-3-phenyl-2-(4-methoxyphenylthio)quinoxaline 
• 1017622-32-0 5,7-dinitro-3-phenyl-2-(3,4-dimethoxyphenylthio)quinoxaline 
• 1148020-94-3 5,7-dinitro-3-phenyl-2-(3,4-dichlorophenylthio)quinoxaline 

Relevant articles and documents

Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: Evaluation of in vitro anti-cancer and anti-folate activities

Several diamino quinoxalines were designed, synthesized and evaluated as anti-tumor agents. Two compounds showed the most potent cytotoxic activities against the leukemia CCRF-CEM cell line (GI50 50 = 0.03 μM), respectively, with comparable/better activities than Methotrexate (MTX). Docking calculations of the complexes of hDHFR with the most active compounds identified the binding mode of the described molecules with respect to MTX.