101089-89-8

Basic information

• Product Name: N-Diphenylmethyl hydroxyacetamide
• Synonyms: N-Diphenylmethyl hydroxyacetamide
• CAS NO: 101089-89-8
• Molecular Weight: 241.29
• Mol File: 101089-89-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-Diphenylmethyl hydroxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Diphenylmethyl hydroxyacetamide(101089-89-8)
• EPA Substance Registry System: N-Diphenylmethyl hydroxyacetamide(101089-89-8)

Safety Data

• Hazardous Substances Data: 101089-89-8(Hazardous Substances Data)

Upstream product

• 119706-04-6 BOC-Ala-OBg 
• 623-50-7 ethyl 2-hydroxyacetate 
• 91-00-9 Benzhydrylamine 
• 10254-07-6 N-benzhydryl-2-chloroacetamide 
• 79-14-1 glycolic Acid 

Downstream Products

• 101878-25-5 methoxycarbonyloxy-acetic acid benzhydrylamide 
• 119706-21-7 2-(benzhydrylamino)-2-oxoethyl ((benzyloxy)carbonyl)-L-valinate 

Relevant articles and documents

Removal of benzhydryl-glycolamide (OBg) group with tetrabutylammonium fluoride

Tetrabutylammonium fluoride (TBAF) in acetonitrile (MeCN) or in N, N- dimethylformamide (DMF) is an alternative to the potassium carbonate hydrolysis in a mixture of DMF and water for the removal of N- Benzhydrylglycolamide esters (OBg) in the solution synthesis of peptide.

N-BENZHYDRYL-GLYCOLAMIDE ESTERS (OBg ESTERS) AS CARBOXYL PROTECTING GROUPS IN PEPTIDE SYNTHESIS

N-benzhydryl-glycolamide esters (OBg esters) of various N-protected amino acids have been synthesized.In order to demonstrate their usefulness in peptide chemistry, the syntheses of For-Met-Leu-Phe-OH (chemiotactic peptide) and Pro-Leu-Gly-NH2 (MIF) have been carried out.OBg esters are compatible with commonly used protecting groups and are cleanly and selectively removed in mild alkaline conditions without any side reaction, except for β-benzyl aspartyl containing sequences.