101094-06-8

Basic information

• Product Name: ethyl 4-(phenylsulfonyl)benzoate
• Synonyms: ethyl 4-(phenylsulfonyl)benzoate
• CAS NO: 101094-06-8
• Molecular Weight: 290.34
• Mol File: 101094-06-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: ethyl 4-(phenylsulfonyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(phenylsulfonyl)benzoate(101094-06-8)
• EPA Substance Registry System: ethyl 4-(phenylsulfonyl)benzoate(101094-06-8)

Safety Data

• Hazardous Substances Data: 101094-06-8(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 98-09-9 benzenesulfonyl chloride 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 
• 640-57-3 phenyltolylsulfone 
• 64-17-5 ethanol 
• 5361-54-6 4-(phenylsulfonyl)benzoic acid 
• 873-55-2 sodium benzenesulfonate 
• 14685-90-6 4-ethoxycarbonylphenylhydrazine 

Downstream Products

• 1361970-40-2 N₁-[4-(phenylsulfonyl)benzoyl]-N₄-(4-trifluoromethoxyphenyl)-thiosemicarbazide 
• 1361970-44-6 N₁-[4-(phenylsulfonyl)benzoyl]-N₄-(3,4,5-trimethoxyphenyl)-thiosemicarbazide 
• 1361970-47-9 5-(4-(phenylsulfonyl)phenyl)-4-(4-trifluoromethoxyphenyl)-2H-1,2,4-triazol-3(4H)-thione 
• 1361970-49-1 5-(4-(phenylsulfonyl)phenyl)-4-(3,4,5-trimethoxyphenyl)-2H-1,2,4-triazol-3(4H)-thione 
• 1361970-51-5 5-(4-(phenylsulfonyl)phenyl)-N-(4-trifluoromethoxyphenyl)-1,3,4-thiadiazol-2-amine 
• 1361970-53-7 5-(4-(phenylsulfonyl)phenyl)-N-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-amine 
• 79849-52-8 C₁₄H₁₃N₃O₃S₂ 
• 5454-36-4 N-(4-benzenesulfonyl-phenyl)-N'-butyl-urea 
• 20721-07-7 p-(Phenylsulphonyl) benzoic acid hydrazide 
• 34661-08-0 4-benzenesulfonyl-benzoyl azide 
• 55204-60-9 4-benzenesulfonyl-benzoic acid amide 
• 21849-33-2 (4-benzenesulfonyl-phenyl)-carbamic acid ethyl ester 
• 7019-01-4 p-aminophenyl phenyl sulfone 

Relevant articles and documents

Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors

Sulfonyl azides have been widely used as sulfonamido, diazo, and azido donors, as well as all-nitrogen 1,3-dipoles donors in synthetic chemistry. Here, the sulfonyl azides were used as efficient sulfonyl donors, which is very unusual. Trifluoromethanesulfonic acid-induced formation of the sulfonyl cation reactive species from sulfonyl azides was developed and used for the first time to couple various inactivated arenes to prepare sulfones at ambient temperature.

Electrochemistry Enabled Nickel-Catalyzed Selective C?S Bond Coupling Reaction

This work describes an electrochemical enabled nickel-catalyzed chemoselective C?S bond coupling protocol for the production of aryl sulfides and sulfones. By simply switching the nickel catalysts and electrodes, this electrochemical C?S bond coupling has demonstrated excellent redox activity, scalability and sustainability. Furthermore, the mechanism for this electrochemical cross-coupling reaction has been investigated.

Synthesis of Sulfones and Sulfonyl Derivatives using Sodium (tert-butyldimethylsilyl)oxymethanesulfinate

The present invention relates to a method for manufacturing a sulfone and sulfonyl derivative compound using sodium (tert-butyldimethylsilyl)oxymethanesulfinate, which is a novel organic sulfin salt, wherein the novel organic sulfin salt has good stability, environmental friendliness and economy, and is easy to handle, and thus significantly reduces the amount of transition metal catalysts and the amount of organic sulfin salts used when introducing aryl or alkenyl. Also, alkylation, arylation, amination, and fluorination are all possible during secondary functionalization. Therefore, the present invention can be usefully used in preparation and mass production of various kinds of sulfones and derivatives thereof including asymmetric sulfone derivatives.

Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent. TBSOMS-Na, easily prepared from the commercial reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles. The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a separate unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.