1011-26-3

Basic information

• Product Name: 2-bromo-4-chlorobutyrophenone
• Synonyms: 2-bromo-4-chlorobutyrophenone;2-bromo-1-(4-chlorophenyl)butan-1-one;1-Butanone,2-broMo-1-(4-chlorophenyl)-
• CAS NO: 1011-26-3
• Molecular Formula: C₁₀H₁₀BrClO
• Molecular Weight: 261.5428
• Mol File: 1011-26-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 39.5 °C
• Boiling Point: 311.7 °C at 760 mmHg
• Flash Point: 142.3 °C
• Appearance: /
• Density: 1.457 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-bromo-4-chlorobutyrophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-chlorobutyrophenone(1011-26-3)
• EPA Substance Registry System: 2-bromo-4-chlorobutyrophenone(1011-26-3)

Safety Data

• Hazardous Substances Data: 1011-26-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-chlorobutyrophenone is a chemical compound with the formula C10H10BrClO. It is a phenyl ketone derivative that is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is a white, crystalline solid with a high melting point, and it is insoluble in water but soluble in organic solvents. Its unique structure makes it a valuable building block in the manufacturing of various chemicals, and it is often used in research and development to create new compounds with specific properties and functions. However, due to its potential health hazards and environmental impacts, its handling and use should be carefully managed and regulated.

Upstream product

• 4981-63-9 4-n-butanoylchlorobenzene 
• 108-90-7 chlorobenzene 

Downstream Products

• 119313-12-1 2-benzyl-2-(dimethylamino)-1-(4-morpholinophenyl)-butan 1-one 
• 158399-93-0 2-[1-(4-chlorobenzoyl)propyl]-2,4-dihydro-4-[6-[4-(4-methoxyphenyl)-1-piperazinyl]-3-pyridinyl]-3H-1,2,4-triazol-3-one 
• 158400-41-0 (+/-)-2-[1-(4-chlorobenzoyl)propyl]-2,4-dihydro-4-[2-[4-(4-methoxyphenyl)-1-piperazinyl]-5-pyrimidinyl]-3H-1,2,4-triazol-3-one 
• 175782-91-9 (+)-2-[1-(4-chlorobenzoyl)propyl]-2,4-dihydro-4-[6-[4-(2-pyrazinyl)-1-piperazinyl]-3-pyridinyl]-3H-1,2,4-triazol-3-one 
• 123979-03-3 1-(4-chlorophenyl)-1,2-propanedione dioxime 
• 948908-05-2 (Z)-1-(4-chlorophenyl)-2-hydroxyamino-1-hydroxyiminopropane 

Relevant articles and documents

Design, synthesis and broad-spectrum Bcr-Abl inhibitory activity of novel thiazolamide-benzamide derivatives

Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid leukemia (CML). But Bcr-Abl is prone to mutation, so it increases the difficulty of clinical treatment. Therefore, it is crucial to design a new class of broad-spectrum Bcr-Abl inhibitors. Herein, forty novel thiazolamide-benzamide derivatives were synthesized and evaluated their broad-spectrum Bcr-Abl inhibitory activities. The newly synthesized compounds were characterized by using spectrum data (1H NMR, APCI-MS and IR) and elemental analysis. The protein kinase results indicated that eight compounds (3a, 3e, 3m, 3n, 3p, 4c, 4f, 4g) showed high activities to wild-type and T315I mutation. The most potent compound 3m exhibited an Abl IC50 value as low as 1.273 μM and showed inhibition to the T315I mutant with IC50 value 39.89 μM. 3m could prove to be a new promising lead compound for the further development of broad-spectrum Bcr-Abl inhibitors to overcome clinical acquired resistance.

A new amino ketone photoinitiator and in UV - LED light curing system application (by machine translation)

The invention provides a method suitable for UV - LED light source setting new amino ketone photo initiator, can in long wave zone (365 - 395 nm) has stronger absorption, UV - LED light source is suitable for curing, has overcome the traditional cured high energy consumption, pollution and shortcomings. Electronic unlocalized is good, with strong intramolecular electron transfer performance and excellent photoelectric nature, in the long-wave region 365 nm - 395 nm range have strong absorption, is suitable for high-power UVLED ultraviolet light curing system, compared with the prior art such optical initiator has a considerable advantage. (by machine translation)

Antifungal azole compounds

This invention relates to novel antifungal azole compound of the formula: STR1 wherein X and Y are CH or N, R1 is optionally substituted phenyl or phenylalkyl, 1-6C alkyl or 3-8C cycloalkyl, R2 and R3 are hydrogen or 1-6C alkyl, and R4 and R5 are hydrogen, NH2, 1-6C alkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylamino or alkenyl wherein each alkyl, alkoxy or alkenyl part is of 1-6C, phenyl, phenyl-(1-6C)-alkyl, phenoxy-(1-6C)-alkyl or phenyl-(2-6C)-alkenyl in which the phenyl may be optionally substituted, or a heterocyclyl, (heterocyclyl)-(1-6C)-alkyl or (heterocyclyl)-(2-6C)-alkenyl in each of which the heterocyclyl ring may be optionally substituted, provided at least one of R2, R3, R4 and R5 is other than hydrogen, and the acid addition salts of those compounds which contain a basic nitrogen; together with processes for their manufacture; compositions containing them; and a method of combatting plant fungal diseases.