1011533-71-3Relevant articles and documents
Catalytic asymmetric total synthesis of (+)-yohimbine
Mergott, Dustin J.,Zuend, Stephan J.,Jacobsen, Eric N.
, p. 745 - 748 (2008)
The total synthesis of (+)yohimbine was achieved in 11 steps and 14% overall yield. The absolute configuration was established through a highly enantioselective thiourea-catalyzed acyl-Pictet-Spengler reaction, and the remaining 4 stereocenters were set simultaneously in a substrate-controlled intramolecular Diels Alder reaction.