1012-17-5 Usage
Description
3-(4-CHLORO-PHENYL)-2-METHYL-PROPIONIC ACID, also known as 2-(4-Chlorobenzyl)propanoic Acid, is a chemical compound with a molecular structure that features a chlorophenyl group attached to a methylpropionic acid backbone. 3-(4-CHLORO-PHENYL)-2-METHYL-PROPIONIC ACID has the potential to modulate biological processes due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
3-(4-CHLORO-PHENYL)-2-METHYL-PROPIONIC ACID is used as a pharmaceutical agent for inhibiting Rho-associated protein kinase. This inhibition can be beneficial in the treatment of various diseases where Rho-associated protein kinase plays a significant role in their progression or pathophysiology.
Used in Research Applications:
In the field of scientific research, 3-(4-CHLORO-PHENYL)-2-METHYL-PROPIONIC ACID serves as a valuable tool compound for studying the role of Rho-associated protein kinase in cellular processes and disease mechanisms. This can aid in the development of targeted therapies and a better understanding of the underlying biology of various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1012-17-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 2 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1012-17:
(6*1)+(5*0)+(4*1)+(3*2)+(2*1)+(1*7)=25
25 % 10 = 5
So 1012-17-5 is a valid CAS Registry Number.
1012-17-5Relevant articles and documents
Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals
Wu, Fu-Peng,Li, Da,Peng, Jin-Bao,Wu, Xiao-Feng
supporting information, p. 5699 - 5703 (2019/08/01)
In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.
Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation
Wang, Zhi-Gang,Chen, Liqun,Chen, Jiebo,Zheng, Jian-Feng,Gao, Weiwei,Zeng, Zhiping,Zhou, Hu,Zhang, Xiao-Kun,Huang, Pei-Qiang,Su, Ying
, p. 632 - 648 (2013/05/09)
RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.